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Article

A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement

Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
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Int. J. Mol. Sci. 2020, 21(18), 6659; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186659
Received: 15 August 2020 / Revised: 7 September 2020 / Accepted: 9 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Novel Extracellular and Intracellular Signalling Mechanisms in Bone)
Inflammatory disorders are associated with bone destruction; that is, deterioration in bone cell activities are under the control of the innate immune system. Macrophages play a central role in innate immunity by switching their polarized phenotype. A disturbed immune system causes aberrance in the ordered bone matrix microarrangement, which is a dominant determinant of bone tissue functionalization. However, the precise relationship between the immune system and bone tissue organization is unknown. In this study, the controlled in vitro co-culture assay results showed that M1-polarized macrophages disrupted the osteoblast alignment, which directly modulate the oriented bone matrix organization, by secreting pro-inflammatory cytokines. Notably, interleukin-6 was found to be a key regulator of unidirectional osteoblast alignment. Our results demonstrated that inflammatory diseases triggered bone dysfunction by regulating the molecular interaction between the immune system and bone tissue organization. These findings may contribute to the development of therapeutic targets for inflammatory disorders, including rheumatoid arthritis. View Full-Text
Keywords: macrophage; osteoblast; cell arrangement; bone microstructure; interleukin-6 macrophage; osteoblast; cell arrangement; bone microstructure; interleukin-6
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MDPI and ACS Style

Matsugaki, A.; Matsumoto, S.; Nakano, T. A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement. Int. J. Mol. Sci. 2020, 21, 6659. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186659

AMA Style

Matsugaki A, Matsumoto S, Nakano T. A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement. International Journal of Molecular Sciences. 2020; 21(18):6659. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186659

Chicago/Turabian Style

Matsugaki, Aira, Shun Matsumoto, and Takayoshi Nakano. 2020. "A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement" International Journal of Molecular Sciences 21, no. 18: 6659. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186659

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