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Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action

Department of Cell Biology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan
Int. J. Mol. Sci. 2020, 21(18), 6665; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186665
Received: 30 July 2020 / Revised: 8 September 2020 / Accepted: 9 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Hedgehog Signaling 2.0)
Hedgehog (Hh) signaling is highly conserved among species and plays indispensable roles in various developmental processes. There are three Hh members in mammals; one of them, Indian hedgehog (Ihh), is expressed in prehypertrophic and hypertrophic chondrocytes during endochondral ossification. Based on mouse genetic studies, three major functions of Ihh have been proposed: (1) Regulation of chondrocyte differentiation via a negative feedback loop formed together with parathyroid hormone-related protein (PTHrP), (2) promotion of chondrocyte proliferation, and (3) specification of bone-forming osteoblasts. Gli transcription factors mediate the major aspect of Hh signaling in this context. Gli3 has dominant roles in the growth plate chondrocytes, whereas Gli1, Gli2, and Gli3 collectively mediate biological functions of Hh signaling in osteoblast specification. Recent studies have also highlighted postnatal roles of the signaling in maintenance and repair of skeletal tissues. View Full-Text
Keywords: hedgehog; skeletal development; endochondral ossification hedgehog; skeletal development; endochondral ossification
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MDPI and ACS Style

Ohba, S. Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action. Int. J. Mol. Sci. 2020, 21, 6665. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186665

AMA Style

Ohba S. Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action. International Journal of Molecular Sciences. 2020; 21(18):6665. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186665

Chicago/Turabian Style

Ohba, Shinsuke. 2020. "Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action" International Journal of Molecular Sciences 21, no. 18: 6665. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186665

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