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Review

Recent Advances in Cell-Based Therapies for Ischemic Stroke

1
Department of Neurology, Nippon Medical School, Tokyo 113-8602, Japan
2
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan
3
Institute for Stroke and Cerebrovascular Disease, UTHealth, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6718; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186718
Received: 28 August 2020 / Revised: 9 September 2020 / Accepted: 10 September 2020 / Published: 14 September 2020
(This article belongs to the Special Issue Neuroregeneration and Brain Repair after Stroke)
Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke. View Full-Text
Keywords: angiogenesis; clinical trial; inflammation; neurogenesis; stem cell; stroke angiogenesis; clinical trial; inflammation; neurogenesis; stem cell; stroke
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MDPI and ACS Style

Suda, S.; Nito, C.; Yokobori, S.; Sakamoto, Y.; Nakajima, M.; Sowa, K.; Obinata, H.; Sasaki, K.; Savitz, S.I.; Kimura, K. Recent Advances in Cell-Based Therapies for Ischemic Stroke. Int. J. Mol. Sci. 2020, 21, 6718. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186718

AMA Style

Suda S, Nito C, Yokobori S, Sakamoto Y, Nakajima M, Sowa K, Obinata H, Sasaki K, Savitz SI, Kimura K. Recent Advances in Cell-Based Therapies for Ischemic Stroke. International Journal of Molecular Sciences. 2020; 21(18):6718. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186718

Chicago/Turabian Style

Suda, Satoshi, Chikako Nito, Shoji Yokobori, Yuki Sakamoto, Masataka Nakajima, Kota Sowa, Hirofumi Obinata, Kazuma Sasaki, Sean I. Savitz, and Kazumi Kimura. 2020. "Recent Advances in Cell-Based Therapies for Ischemic Stroke" International Journal of Molecular Sciences 21, no. 18: 6718. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186718

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