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Case Report

Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient

1
INSERM, CHU-Lille, U1189—ONCO-THAI—Assisted Laser Therapy and Immunotherapy for Oncology, University of Lille, F-59000 Lille, France
2
Immune Insight, Institut de Biologie de Lille, 59021 Lille, France
3
CNRS UMS 3702, Institut de Biologie de Lille, 59021 Lille, France
4
Service de Radiothérapie, Centre Oscar Lambret, 59000 Lille, France
5
Service de Dermatologie, Hôpital Huriez, 59000 Lille, France
*
Authors to whom correspondence should be addressed.
These authors have equally contributed.
Int. J. Mol. Sci. 2020, 21(18), 6772; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186772
Received: 15 July 2020 / Revised: 4 September 2020 / Accepted: 8 September 2020 / Published: 15 September 2020
(This article belongs to the Special Issue Recent Advances in T Cell Immunity)
The development of immunotherapy has recently modified the anti-tumor therapeutic arsenal; particularly, immune checkpoint inhibitors have led to a significant increase in overall survival. The current challenge is now to select good responder patients by identifying early biomarkers to propose therapeutic combinations that potentiate the efficacy of the therapy. Here we report the case of a 60-year-old man with superficial melanoma treated with high-dose hypo fractionated radiotherapy (H-SRT) combined with a single dose of anti-PD1 immunotherapy (Nivolumab) for a metastatic lymph node recurrence due to cancer progression. In this study, we present the results obtained regarding the activation of the Th1 immune response after H-SRT treatment followed by anti PD-1 therapeutic protocol. These results were correlated with clinical data to identify potential immunological biomarkers of treatment efficacy. This exceptional case report shows that a combination of H-SRT with a single dose of anti-PD1 immunotherapy may allow a better activation of the immune response in favor of a complete clinical response. View Full-Text
Keywords: stereotaxic radiotherapy; immunotherapy; anti-PD1; melanoma; immune response stereotaxic radiotherapy; immunotherapy; anti-PD1; melanoma; immune response
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MDPI and ACS Style

Milhem, C.; Moralès, O.; Ingelaere, C.; Pasquier, D.; Mordon, S.; Mortier, L.; Mirabel, X.; Delhem, N. Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient. Int. J. Mol. Sci. 2020, 21, 6772. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186772

AMA Style

Milhem C, Moralès O, Ingelaere C, Pasquier D, Mordon S, Mortier L, Mirabel X, Delhem N. Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient. International Journal of Molecular Sciences. 2020; 21(18):6772. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186772

Chicago/Turabian Style

Milhem, Clara, Olivier Moralès, Céline Ingelaere, David Pasquier, Serge Mordon, Laurent Mortier, Xavier Mirabel, and Nadira Delhem. 2020. "Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient" International Journal of Molecular Sciences 21, no. 18: 6772. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186772

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