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Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action

The Role of Smoothened in Cancer

Division of General Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan
Department of Hepato-Gastroenterology, Chang-Gung Memorial Hospital, Linkou Medical Center, Chang-Gung University, Taoyuan City 33305, Taiwan
Institute of Microbiology and Immunology, National Yang-Ming University, Taipei City 11221, Taiwan
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei City 11221, Taiwan
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6863;
Received: 30 July 2020 / Revised: 13 September 2020 / Accepted: 15 September 2020 / Published: 18 September 2020
(This article belongs to the Special Issue Hedgehog Signaling 2.0)
Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches. View Full-Text
Keywords: Smoothened; Hedgehog signaling pathway; cancer stem cells Smoothened; Hedgehog signaling pathway; cancer stem cells
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MDPI and ACS Style

Jeng, K.-S.; Sheen, I.-S.; Leu, C.-M.; Tseng, P.-H.; Chang, C.-F. The Role of Smoothened in Cancer. Int. J. Mol. Sci. 2020, 21, 6863.

AMA Style

Jeng K-S, Sheen I-S, Leu C-M, Tseng P-H, Chang C-F. The Role of Smoothened in Cancer. International Journal of Molecular Sciences. 2020; 21(18):6863.

Chicago/Turabian Style

Jeng, Kuo-Shyang, I-Shyan Sheen, Chuen-Miin Leu, Ping-Hui Tseng, and Chiung-Fang Chang. 2020. "The Role of Smoothened in Cancer" International Journal of Molecular Sciences 21, no. 18: 6863.

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