Connections between Metabolism and Epigenetic Modification in MDSCs
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China
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Int. J. Mol. Sci. 2020, 21(19), 7356; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197356
Received: 31 August 2020 / Revised: 23 September 2020 / Accepted: 24 September 2020 / Published: 5 October 2020
(This article belongs to the Special Issue Progress in Glucose Metabolism)
Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells in the tumor microenvironment (TME). During the differentiation and development of MDSCs from myeloid progenitor cells, their functions are also affected by a series of regulatory factors in the TME, such as metabolic reprogramming, epigenetic modification, and cell signaling pathways. Additionally, there is a crosstalk between these regulatory factors. This review mainly introduces the metabolism (especially glucose metabolism) and significant epigenetic modification of MDSCs in the TME, and briefly introduces the connections between metabolism and epigenetic modification in MDSCs, in order to determine the further impact on the immunosuppressive effect of MDSCs, so as to serve as a more effective target for tumor therapy.
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Keywords:
MDSCs; metabolism; epigenetic modification; AMPK; HIF-1α
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MDPI and ACS Style
Dai, H.; Xu, H.; Wang, S.; Ma, J. Connections between Metabolism and Epigenetic Modification in MDSCs. Int. J. Mol. Sci. 2020, 21, 7356. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197356
AMA Style
Dai H, Xu H, Wang S, Ma J. Connections between Metabolism and Epigenetic Modification in MDSCs. International Journal of Molecular Sciences. 2020; 21(19):7356. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197356
Chicago/Turabian StyleDai, Haiyan; Xu, Huaxi; Wang, Shengjun; Ma, Jie. 2020. "Connections between Metabolism and Epigenetic Modification in MDSCs" Int. J. Mol. Sci. 21, no. 19: 7356. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197356
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