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Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches

Genetic Aspects of Inflammation and Immune Response in Stroke

Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Physical Medicine and Rehabilitation Department, University Children’s Hospital, 11000 Belgrade, Serbia
Neurology Clinic, Clinical Center of Serbia, 11000 Belgrade, Serbia
Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, 11000 Belgrade, Serbia
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7409;
Received: 13 September 2020 / Revised: 1 October 2020 / Accepted: 5 October 2020 / Published: 8 October 2020
(This article belongs to the Special Issue Immunoinflammatory Background of Neuronal Damage in Stroke)
Genetic determinants play important role in the complex processes of inflammation and immune response in stroke and could be studied in different ways. Inflammation and immunomodulation are associated with repair processes in ischemic stroke, and together with the concept of preconditioning are promising modes of stroke treatment. One of the important aspects to be considered in the recovery of patients after the stroke is a genetic predisposition, which has been studied extensively. Polymorphisms in a number of candidate genes, such as IL-6, BDNF, COX2, CYPC19, and GPIIIa could be associated with stroke outcome and recovery. Recent GWAS studies pointed to the variant in genesPATJ and LOC as new genetic markers of long term outcome. Epigenetic regulation of immune response in stroke is also important, with mechanisms of histone modifications, DNA methylation, and activity of non-coding RNAs. These complex processes are changing from acute phase over the repair to establishing homeostasis or to provoke exaggerated reaction and death. Pharmacogenetics and pharmacogenomics of stroke cures might also be evaluated in the context of immuno-inflammation and brain plasticity. Potential novel genetic treatment modalities are challenged but still in the early phase of the investigation. View Full-Text
Keywords: genetics; inflammation; stroke; treatment; recovery genetics; inflammation; stroke; treatment; recovery
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MDPI and ACS Style

Nikolic, D.; Jankovic, M.; Petrovic, B.; Novakovic, I. Genetic Aspects of Inflammation and Immune Response in Stroke. Int. J. Mol. Sci. 2020, 21, 7409.

AMA Style

Nikolic D, Jankovic M, Petrovic B, Novakovic I. Genetic Aspects of Inflammation and Immune Response in Stroke. International Journal of Molecular Sciences. 2020; 21(19):7409.

Chicago/Turabian Style

Nikolic, Dejan, Milena Jankovic, Bojana Petrovic, and Ivana Novakovic. 2020. "Genetic Aspects of Inflammation and Immune Response in Stroke" International Journal of Molecular Sciences 21, no. 19: 7409.

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