Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity
Round 1
Reviewer 1 Report
A very good review of the cytotoxin-associated protein H. pylori - CagA. I have no fundamental remarks
Author Response
Thank you very much for your positive comments.
Reviewer 2 Report
The manuscript is quite well written.
It represents a comprehensive review of the field.
The authors discuss the possible role of CagA in gastric pathogenicity.
Several virulence factors, including cytotoxin-associated gene A (CagA), which
is translocated into the gastric epithelium via the type 4 secretory system
(T4SS), have been indicated to play a crucial role in disease development.
Although infection with strains harboring the East Asian type of CagA
possessing the EPIYA-A, B, and -D sequences has been found to potentiate cell
proliferation and disease pathogenicity, the exact mechanism of CagA
involvement in disease severity still remains to be elucidated.
It would be useful for the readers to include the discussion of
PMID: 9247587.
Author Response
Thank you very much for your positive comments.
