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Review

HMGA Genes and Proteins in Development and Evolution

Dipartimento di Biologia, Unità di Biologia Cellulare e dello Sviluppo, Università di Pisa, 56126 Pisa, Italy
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Int. J. Mol. Sci. 2020, 21(2), 654; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020654
Received: 20 December 2019 / Revised: 14 January 2020 / Accepted: 16 January 2020 / Published: 19 January 2020
(This article belongs to the Special Issue HMG Proteins in Development and Disease)
HMGA (high mobility group A) (HMGA1 and HMGA2) are small non-histone proteins that can bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors to the DNA and contributing to the overall panorama of gene expression tuning. In general, they are abundantly expressed during embryogenesis, but are downregulated in the adult differentiated tissues. In the present review, we summarize some aspects of their role during development, also dealing with relevant studies that have shed light on their functioning in cell biology and with emerging possible involvement of HMGA1 and HMGA2 in evolutionary biology. View Full-Text
Keywords: HMGA1; HMGA2; development; chromatin remodeling; AT hook; cell cycle; EMT; stemness; evolution; differentiation HMGA1; HMGA2; development; chromatin remodeling; AT hook; cell cycle; EMT; stemness; evolution; differentiation
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MDPI and ACS Style

Vignali, R.; Marracci, S. HMGA Genes and Proteins in Development and Evolution. Int. J. Mol. Sci. 2020, 21, 654. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020654

AMA Style

Vignali R, Marracci S. HMGA Genes and Proteins in Development and Evolution. International Journal of Molecular Sciences. 2020; 21(2):654. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020654

Chicago/Turabian Style

Vignali, Robert, and Silvia Marracci. 2020. "HMGA Genes and Proteins in Development and Evolution" International Journal of Molecular Sciences 21, no. 2: 654. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020654

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