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Article

Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces

1
Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA
2
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
3
Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa 232-0024, Japan
4
Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemori-dori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan
5
Division of Prosthodontics and Oral Rehabilitation, Department of Oral Function and Restoration, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 660; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020660
Received: 17 December 2019 / Revised: 15 January 2020 / Accepted: 16 January 2020 / Published: 19 January 2020
(This article belongs to the Special Issue Functional Materials for Bone Regeneration: Biomaterials and Cells)
Ultraviolet treatment of titanium implants makes their surfaces hydrophilic and enhances osseointegration. However, the mechanism is not fully understood. This study hypothesizes that the recruitment of fibrinogen, a critical molecule for blood clot formation and wound healing, is influenced by the degrees of hydrophilicity/hydrophobicity of the implant surfaces. Computational fluid dynamics (CFD) implant models were created for fluid flow simulation. The hydrophilicity level was expressed by the contact angle between the implant surface and blood plasma, ranging from 5° (superhydrophilic), 30° (hydrophilic) to 50° and 70° (hydrophobic), and 100° (hydrorepellent). The mass of fibrinogen flowing into the implant interfacial zone (fibrinogen infiltration) increased in a time dependent manner, with a steeper slope for surfaces with greater hydrophilicity. The mass of blood plasma absorbed into the interfacial zone (blood plasma infiltration) was also promoted by the hydrophilic surfaces but it was rapid and non-time-dependent. There was no linear correlation between the fibrinogen infiltration rate and the blood plasma infiltration rate. These results suggest that hydrophilic implant surfaces promote both fibrinogen and blood plasma infiltration to their interface. However, the infiltration of the two components were not proportional, implying a selectively enhanced recruitment of fibrinogen by hydrophilic implant surfaces. View Full-Text
Keywords: fibrinogen; computational fluid dynamics; dental implant surface; contact angle; hydrophilicity; blood flow; ultraviolet fibrinogen; computational fluid dynamics; dental implant surface; contact angle; hydrophilicity; blood flow; ultraviolet
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MDPI and ACS Style

Kitajima, H.; Hirota, M.; Iwai, T.; Hamajima, K.; Ozawa, R.; Hayashi, Y.; Yajima, Y.; Iida, M.; Koizumi, T.; Kioi, M.; Mitsudo, K.; Ogawa, T. Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces. Int. J. Mol. Sci. 2020, 21, 660. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020660

AMA Style

Kitajima H, Hirota M, Iwai T, Hamajima K, Ozawa R, Hayashi Y, Yajima Y, Iida M, Koizumi T, Kioi M, Mitsudo K, Ogawa T. Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces. International Journal of Molecular Sciences. 2020; 21(2):660. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020660

Chicago/Turabian Style

Kitajima, Hiroaki, Makoto Hirota, Toshinori Iwai, Kosuke Hamajima, Ryotaro Ozawa, Yuichiro Hayashi, Yasuharu Yajima, Masaki Iida, Toshiyuki Koizumi, Mitomu Kioi, Kenji Mitsudo, and Takahiro Ogawa. 2020. "Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces" International Journal of Molecular Sciences 21, no. 2: 660. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020660

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