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Review

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

1
ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea
2
Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul 05505, Korea
3
Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 665; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020665
Received: 20 December 2019 / Revised: 15 January 2020 / Accepted: 16 January 2020 / Published: 19 January 2020
(This article belongs to the Special Issue Exosomes in Cancer Diagnosis and Therapy)
Exosomes are nano-sized membranous vesicles produced by nearly all types of cells. Since exosome-like vesicles are produced in an evolutionarily conserved manner for information and function transfer from the originating cells to recipient cells, an increasing number of studies have focused on their application as therapeutic agents, drug delivery vehicles, and diagnostic targets. Analysis of the in vivo distribution of exosomes is a prerequisite for the development of exosome-based therapeutics and drug delivery vehicles with accurate prediction of therapeutic dose and potential side effects. Various attempts to evaluate the biodistribution of exosomes obtained from different sources have been reported. In this review, we examined the current trends and the advantages and disadvantages of the methods used to determine the biodistribution of exosomes by molecular imaging. We also reviewed 29 publications to compare the methods employed to isolate, analyze, and label exosomes as well as to determine the biodistribution of labeled exosomes. View Full-Text
Keywords: biodistribution; exosomes; labeling; molecular imaging; therapeutics biodistribution; exosomes; labeling; molecular imaging; therapeutics
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MDPI and ACS Style

Yi, Y.W.; Lee, J.H.; Kim, S.-Y.; Pack, C.-G.; Ha, D.H.; Park, S.R.; Youn, J.; Cho, B.S. Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging. Int. J. Mol. Sci. 2020, 21, 665. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020665

AMA Style

Yi YW, Lee JH, Kim S-Y, Pack C-G, Ha DH, Park SR, Youn J, Cho BS. Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging. International Journal of Molecular Sciences. 2020; 21(2):665. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020665

Chicago/Turabian Style

Yi, Yong W., Jun H. Lee, Sang-Yeob Kim, Chan-Gi Pack, Dae H. Ha, Sang R. Park, Jinkwon Youn, and Byong S. Cho 2020. "Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging" International Journal of Molecular Sciences 21, no. 2: 665. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020665

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