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Review

Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia

1
Department of Neurology, University of Kentucky, Lexington, KY 40536, USA
2
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA
3
Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 679; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020679
Received: 18 November 2019 / Revised: 9 January 2020 / Accepted: 16 January 2020 / Published: 20 January 2020
(This article belongs to the Special Issue Extracellular Matrix in Development and Disease 2.0)
Perlecan is a heparan sulfate proteoglycan protein in the extracellular matrix that structurally and biochemically supports the cerebrovasculature by dynamically responding to changes in cerebral blood flow. These changes in perlecan expression seem to be contradictory, ranging from neuroprotective and angiogenic to thrombotic and linked to lipid retention. This review investigates perlecan’s influence on risk factors such as diabetes, hypertension, and amyloid that effect Vascular contributions to Cognitive Impairment and Dementia (VCID). VCID, a comorbidity with diverse etiology in sporadic Alzheimer’s disease (AD), is thought to be a major factor that drives the overall clinical burden of dementia. Accordingly, changes in perlecan expression and distribution in response to VCID appears to be injury, risk factor, location, sex, age, and perlecan domain dependent. While great effort has been made to understand the role of perlecan in VCID, additional studies are needed to increase our understanding of perlecan’s role in health and in cerebrovascular disease. View Full-Text
Keywords: perlecan; extracellular matrix; basement membrane; VCID; vascular risk factors; and dementia perlecan; extracellular matrix; basement membrane; VCID; vascular risk factors; and dementia
MDPI and ACS Style

Trout, A.L.; Rutkai, I.; Biose, I.J.; Bix, G.J. Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia. Int. J. Mol. Sci. 2020, 21, 679. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020679

AMA Style

Trout AL, Rutkai I, Biose IJ, Bix GJ. Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia. International Journal of Molecular Sciences. 2020; 21(2):679. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020679

Chicago/Turabian Style

Trout, Amanda L., Ibolya Rutkai, Ifechukwude J. Biose, and Gregory J. Bix 2020. "Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia" International Journal of Molecular Sciences 21, no. 2: 679. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020679

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