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Communication

MGMT Promoter Methylation and IDH1 Mutations Do Not Affect [18F]FDOPA Uptake in Primary Brain Tumors

1
Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, Italy
2
Nuclear Medicine Section, IRCCS Neuromed, 86077 Pozzilli, Italy
3
Neuro-Oncology Unit, Regina Elena National Cancer Institute, 00144 Rome, Italy
4
Department of Surgical Science, Tor Vergata (PTV) University, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(20), 7598; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21207598
Received: 14 September 2020 / Revised: 12 October 2020 / Accepted: 13 October 2020 / Published: 14 October 2020
The aim of our study was to investigate the effects of methylation of O⁶-methylguanine-DNA methyltransferase promoter (MGMTp) and isocitrate dehydrogenase 1 (IDH 1) mutations on amino acid metabolism evaluated with 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine ([18F] FDOPA) positron emission tomography/computed tomography (PET/CT). Seventy-two patients with primary brain tumors were enrolled in the study (33 women and 39 men; mean age 44 ± 12 years old). All of them were subjected to PET/CT examination after surgical treatment. Of them, 29 (40.3%) were affected by grade II glioma and 43 (59.7%) by grade III. PET/CT was scored as positive or negative and standardized uptake value ratio (SUVr) was calculated as the ratio between SUVmax of the lesion vs that of the background. Statistical analysis was performed with the Mann–Whitney U test. Methylation of MGMTp was detectable in 61 out of the 72 patients examinated. Mean SUVr in patients without methylation of MGMTp was 1.44 ± 0,38 vs. 1.35 ± 0.48 of patients with methylation (p = 0.15). Data on IDH1 mutations were available for 43 subjects; of them, 31 are IDH-mutant. Mean SUVr was 1.38 ± 0.51 in patients IDH mutant and 1.46 ± 0.56 in patients IDH wild type. MGMTp methylation and IDH1 mutations do not affect [18F] FDOPA uptake in primary brain tumors and therefore cannot be assessed or predicted by radiopharmaceutical uptake parameters. View Full-Text
Keywords: Primary brain tumors; nuclear medicine; positron emission tomography; [18F]FDOPA; MGMT promoter methylation; IDH1 mutation; radiopharmaceuticals Primary brain tumors; nuclear medicine; positron emission tomography; [18F]FDOPA; MGMT promoter methylation; IDH1 mutation; radiopharmaceuticals
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MDPI and ACS Style

Cimini, A.; Chiaravalloti, A.; Ricci, M.; Villani, V.; Vanni, G.; Schillaci, O. MGMT Promoter Methylation and IDH1 Mutations Do Not Affect [18F]FDOPA Uptake in Primary Brain Tumors. Int. J. Mol. Sci. 2020, 21, 7598. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21207598

AMA Style

Cimini A, Chiaravalloti A, Ricci M, Villani V, Vanni G, Schillaci O. MGMT Promoter Methylation and IDH1 Mutations Do Not Affect [18F]FDOPA Uptake in Primary Brain Tumors. International Journal of Molecular Sciences. 2020; 21(20):7598. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21207598

Chicago/Turabian Style

Cimini, Andrea, Agostino Chiaravalloti, Maria Ricci, Veronica Villani, Gianluca Vanni, and Orazio Schillaci. 2020. "MGMT Promoter Methylation and IDH1 Mutations Do Not Affect [18F]FDOPA Uptake in Primary Brain Tumors" International Journal of Molecular Sciences 21, no. 20: 7598. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21207598

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