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Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia
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Int. J. Mol. Sci. 2020, 21(21), 7902; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217902
Received: 24 September 2020 / Revised: 21 October 2020 / Accepted: 22 October 2020 / Published: 24 October 2020
Cardiovascular diseases and cancer, the leading causes of morbidity and mortality in the elderly, share some common mechanisms, in particular inflammation, contributing to their progression and pathogenesis. However, somatic mutagenesis, a driving force in cancer development, has not been generally considered as an important factor in cardiovascular disease pathology. Recent studies demonstrated that during normal aging, somatic mutagenesis occurs in blood cells, often resulting in expansion of mutant clones that dominate hematopoiesis at advanced age. This clonal hematopoiesis is primarily associated with mutations in certain leukemia-related driver genes and, being by itself relatively benign, not only increases the risks of subsequent malignant hematopoietic transformation, but, unexpectedly, has a significant impact on progression of atherosclerosis and cardiovascular diseases. In this review, we discuss the phenomenon of clonal hematopoiesis, the most important genes involved in it, its impact on cardiovascular diseases, and relevant aspects of hematopoietic stem cell biology. View Full-Text
Keywords: clonal hematopoiesis; hematopoietic stem cells; somatic mutagenesis; atherosclerosis; cardiovascular diseases; inflammatory cytokines; DNMT3A; TET2; JAK2 clonal hematopoiesis; hematopoietic stem cells; somatic mutagenesis; atherosclerosis; cardiovascular diseases; inflammatory cytokines; DNMT3A; TET2; JAK2
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MDPI and ACS Style

Kandarakov, O.; Belyavsky, A. Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells. Int. J. Mol. Sci. 2020, 21, 7902. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217902

AMA Style

Kandarakov O, Belyavsky A. Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells. International Journal of Molecular Sciences. 2020; 21(21):7902. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217902

Chicago/Turabian Style

Kandarakov, Oleg, and Alexander Belyavsky. 2020. "Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells" International Journal of Molecular Sciences 21, no. 21: 7902. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217902

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