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The Ups and Downs of Metabolism during the Lifespan of a T Cell

Relationship of 2D Affinity to T Cell Functional Outcomes

Department of Pathology, University of Utah, 15 N Medical Drive, Salt Lake City, UT 84112, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7969;
Received: 10 September 2020 / Revised: 14 October 2020 / Accepted: 23 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue Recent Advances in T Cell Immunity)
T cells are critical for a functioning adaptive immune response and a strong correlation exists between T cell responses and T cell receptor (TCR): peptide-loaded MHC (pMHC) binding. Studies that utilize pMHC tetramer, multimers, and assays of three-dimensional (3D) affinity have provided advancements in our understanding of T cell responses across different diseases. However, these technologies focus on higher affinity and avidity T cells while missing the lower affinity responders. Lower affinity TCRs in expanded polyclonal populations almost always constitute a significant proportion of the response with cells mediating different effector functions associated with variation in the proportion of high and low affinity T cells. Since lower affinity T cells expand and are functional, a fully inclusive view of T cell responses is required to accurately interpret the role of affinity for adaptive T cell immunity. For example, low affinity T cells are capable of inducing autoimmune disease and T cells with an intermediate affinity have been shown to exhibit an optimal anti-tumor response. Here, we focus on how affinity of the TCR may relate to T cell phenotype and provide examples where 2D affinity influences functional outcomes. View Full-Text
Keywords: pMHC; TCR; affinity; bond lifetime; T cells; 2D kinetics pMHC; TCR; affinity; bond lifetime; T cells; 2D kinetics
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MDPI and ACS Style

Kolawole, E.M.; Lamb, T.J.; Evavold, B.D. Relationship of 2D Affinity to T Cell Functional Outcomes. Int. J. Mol. Sci. 2020, 21, 7969.

AMA Style

Kolawole EM, Lamb TJ, Evavold BD. Relationship of 2D Affinity to T Cell Functional Outcomes. International Journal of Molecular Sciences. 2020; 21(21):7969.

Chicago/Turabian Style

Kolawole, Elizabeth M., Tracey J. Lamb, and Brian D. Evavold. 2020. "Relationship of 2D Affinity to T Cell Functional Outcomes" International Journal of Molecular Sciences 21, no. 21: 7969.

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