The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9–12 Vitamins
Abstract
:1. Introduction
2. Results
3. Discussion
3.1. The Correction of B-Vitamin Deficiency Did Not Lead to the Rescue of All Body Parameters
3.2. The Initial B-Vitamin Deficiency Provokes Persistent Cognitive Deficits Corrected by the Interventional Stimulation of Neurogenesis
3.3. Various Tissue Parameters Attested of a Rescue Mechanism
4. Methods
4.1. Animal Treatments
4.2. Exposure to Hypoxia
4.3. Biochemical Analyses
4.4. Behavioral Test
4.5. Histopathological Measurements
4.6. Quantification of Proteins
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Pourié, G.; Martin, N.; Daval, J.-L.; Alberto, J.-M.; Umoret, R.; Guéant, J.-L.; Bossenmeyer-Pourié, C. The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9–12 Vitamins. Int. J. Mol. Sci. 2020, 21, 8008. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218008
Pourié G, Martin N, Daval J-L, Alberto J-M, Umoret R, Guéant J-L, Bossenmeyer-Pourié C. The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9–12 Vitamins. International Journal of Molecular Sciences. 2020; 21(21):8008. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218008
Chicago/Turabian StylePourié, Grégory, Nicolas Martin, Jean-Luc Daval, Jean-Marc Alberto, Rémy Umoret, Jean-Louis Guéant, and Carine Bossenmeyer-Pourié. 2020. "The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9–12 Vitamins" International Journal of Molecular Sciences 21, no. 21: 8008. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218008