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Review

SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis

by 1,2, 1,3, 1 and 1,2,*
1
Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education & Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, Wuhan 430070, Hubei, China
2
Bio-Medical Center of Huazhong Agricultural University, Wuhan 430070, Hubei, China
3
Institute of Biomedical Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8208; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218208
Received: 21 September 2020 / Revised: 27 October 2020 / Accepted: 28 October 2020 / Published: 2 November 2020
Lipid homeostasis is essential for normal cell physiology. Generally, lipids are stored in a lipid droplet (LD), a ubiquitous organelle consisting of a neutral lipid core and a single layer of phospholipid membrane. It is thought that LDs are generated from the endoplasmic reticulum and then released into the cytosol. Recent studies indicate that LDs can exist in the nucleus, where they play an important role in the maintenance of cell phospholipid homeostasis. However, the details of nuclear lipid droplet (nLD) generation have not yet been clearly characterized. SEIPIN is a nonenzymatic protein encoded by the Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene. It is associated with lipodystrophy diseases. Many recent studies have indicated that SEIPIN is essential for LDs generation. Here, we review much of this research in an attempt to explain the role of SEIPIN in nLD generation. From an integrative perspective, we conclude by proposing a theoretical model to explain how SEIPIN might participate in maintaining homeostasis of lipid metabolism. View Full-Text
Keywords: nuclear; lipid droplet; SEIPIN; lipid homeostasis nuclear; lipid droplet; SEIPIN; lipid homeostasis
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MDPI and ACS Style

Jin, Y.; Tan, Y.; Zhao, P.; Ren, Z. SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis. Int. J. Mol. Sci. 2020, 21, 8208. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218208

AMA Style

Jin Y, Tan Y, Zhao P, Ren Z. SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis. International Journal of Molecular Sciences. 2020; 21(21):8208. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218208

Chicago/Turabian Style

Jin, Yi, Yanjie Tan, Pengxiang Zhao, and Zhuqing Ren. 2020. "SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis" International Journal of Molecular Sciences 21, no. 21: 8208. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218208

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