Effects of PACAP on Schwann Cells: Focus on Nerve Injury
Abstract
:1. Introduction
2. Schwann Cells and Nerve Injury
3. Overview of PACAP and Its Receptors
4. Effect of PACAP on Schwann Cells during Nerve Injury
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Key Findings | Model | Reference |
---|---|---|
The treatment of PACAP increased myelin protein expression in Schwann cells and inhibited the release of pro-inflammatory cytokines. | Schwann cells from sciatic nerve and brachial plexus of Sprague Dawley rats | [32] |
The treatment of PACAP increased survival of serum-deprived Schwannoma cells. | RT4-P6D2T rat schwannoma cell line | [78] |
The expression of PACAP and its receptors is significantly increased in Schwann cells exposed to serum starvation. The treatment with PACAP exacerbated starvation-induced expression of myelin markers via PI3K/Akt signaling pathways. | RT4-P6D2T rat schwannoma cell line | [79] |
PACAP is up regulated in the cultured vagus nerve. It could involve stimulation of cells surrounding the regenerating nerve fibers including Schwann cells. | Cultured rat vagus nerve | [86] |
In PACAP-deficient mice, the recovery of reinnervation is delayed, and axonal growth is impaired. | PACAP KO mice | [87] |
The exposure of Schwann cells to lipopolysaccharide, to mimic the local inflammatory milieu, increased the expression of PACAP. | RT4-P6D2T rat schwannoma cell line | [91] |
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Maugeri, G.; D’Amico, A.G.; Musumeci, G.; Reglodi, D.; D’Agata, V. Effects of PACAP on Schwann Cells: Focus on Nerve Injury. Int. J. Mol. Sci. 2020, 21, 8233. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218233
Maugeri G, D’Amico AG, Musumeci G, Reglodi D, D’Agata V. Effects of PACAP on Schwann Cells: Focus on Nerve Injury. International Journal of Molecular Sciences. 2020; 21(21):8233. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218233
Chicago/Turabian StyleMaugeri, Grazia, Agata Grazia D’Amico, Giuseppe Musumeci, Dora Reglodi, and Velia D’Agata. 2020. "Effects of PACAP on Schwann Cells: Focus on Nerve Injury" International Journal of Molecular Sciences 21, no. 21: 8233. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218233