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Open AccessReview

Review of PIP2 in Cellular Signaling, Functions and Diseases

Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Int. J. Mol. Sci. 2020, 21(21), 8342; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218342
Received: 21 September 2020 / Revised: 30 October 2020 / Accepted: 3 November 2020 / Published: 6 November 2020
(This article belongs to the Special Issue Phosphoinositides and Downstream Signalling Molecules)
Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2). The levels of PIP2 in the membrane are rapidly altered by the activity of phosphoinositide-directed kinases and phosphatases, and it binds to dozens of different intracellular proteins. Despite the vast literature dedicated to understanding the regulation of PIP2 in cells over past 30 years, much remains to be learned about its cellular functions. In this review, we focus on past and recent exciting results on different molecular mechanisms that regulate cellular functions by binding of specific proteins to PIP2 or by stabilizing phosphoinositide pools in different cellular compartments. Moreover, this review summarizes recent findings that implicate dysregulation of PIP2 in many diseases View Full-Text
Keywords: Phosphoinositides; PIP2; membrane dynamics; actin; intracellular trafficking; focal adhesion; diseases Phosphoinositides; PIP2; membrane dynamics; actin; intracellular trafficking; focal adhesion; diseases
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MDPI and ACS Style

Mandal, K. Review of PIP2 in Cellular Signaling, Functions and Diseases. Int. J. Mol. Sci. 2020, 21, 8342. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218342

AMA Style

Mandal K. Review of PIP2 in Cellular Signaling, Functions and Diseases. International Journal of Molecular Sciences. 2020; 21(21):8342. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218342

Chicago/Turabian Style

Mandal, Kalpana. 2020. "Review of PIP2 in Cellular Signaling, Functions and Diseases" Int. J. Mol. Sci. 21, no. 21: 8342. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218342

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