Next Article in Journal
Aux/IAA14 Regulates microRNA-Mediated Cold Stress Response in Arabidopsis Roots
Next Article in Special Issue
Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase
Previous Article in Journal
BDNF rs6265 Polymorphism and Its Methylation in Patients with Stroke Undergoing Rehabilitation
Article

Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects

1
COSMAX BTI R&I Center, Material Lab, Pangyo Inno Valley E 255, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13486, Korea
2
Syntivia, Centre Pierre Potier, 1 place Pierre Potier, Entrée BP 50624, 31106 Toulouse, France
3
BIO-FD&C Co., Smart Valley A-510, 30 Songdomirae-ro, Yeonsu-gu 21990, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(22), 8439; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228439
Received: 28 August 2020 / Revised: 30 October 2020 / Accepted: 6 November 2020 / Published: 10 November 2020
(This article belongs to the Special Issue Molecular Mechanisms of Skin Aging and Atopic Dermatitis)
In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationship between the secretion of emotion-related hormones and skin aging. Kisspeptin, a neuropeptide encoded by the KISS1 gene, has gained attention in reproductive endocrinology since it stimulates the reproductive axis in the hypothalamus; however, the effects of Kisspeptin on skin have not been studied yet. In this study, we synthesized Kisspeptin-10 and Kisspeptin-E, which are biologically active fragments, to mimic the action of Kisspeptin. Next, we demonstrated the anti-aging effects of the Kisspeptin-mimicking fragments using UV-induced skin aging models, such as UV-induced human dermal fibroblasts (Hs68) and human skin explants. Kisspeptin-E suppressed UV-induced 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) stimulation leading to a regulation of skin aging related genes, including type I procollagen, matrix metalloproteinases-1 (MMP-1), interleukin-6 (IL-6), and IL-8, and rescued the skin integrity. Taken together, these results suggest that Kisspeptin-E could be useful to improve UV-induced skin aging by modulating expression of stress related genes, such as 11β-HSD1. View Full-Text
Keywords: Kisspeptin-mimicking fragments; 11β-HSD1; collagen; skin aging; MMP-1 Kisspeptin-mimicking fragments; 11β-HSD1; collagen; skin aging; MMP-1
Show Figures

Figure 1

MDPI and ACS Style

Lee, K.-E.; Jeong, S.; Yun, S.K.; Kyung, S.; Sophie, A.; Moh, S.H.; Seo, H.H.; Park, M.S.; Kang, S.; Yeo, H. Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects. Int. J. Mol. Sci. 2020, 21, 8439. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228439

AMA Style

Lee K-E, Jeong S, Yun SK, Kyung S, Sophie A, Moh SH, Seo HH, Park MS, Kang S, Yeo H. Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects. International Journal of Molecular Sciences. 2020; 21(22):8439. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228439

Chicago/Turabian Style

Lee, Kyung-Eun; Jeong, Sugyeong; Yun, Seok K.; Kyung, Seoyeon; Sophie, Abadie; Moh, Sang H.; Seo, Hyo H.; Park, Myeong S.; Kang, Seunghyun; Yeo, Hyeonju. 2020. "Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects" Int. J. Mol. Sci. 21, no. 22: 8439. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228439

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop