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Article

Efficiency of Hydroxycinnamic Phenolic Acids to Inhibit the Production of Ochratoxin A by Aspergillus westerdijkiae and Penicillium verrucosum

1
Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai 57100, Thailand
2
School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
3
UR1264 Mycology and Food Safety Research Unit (MycSA), INRAE Research Centre, F-22882 Villenave d’Ornon, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(22), 8548; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228548
Received: 30 September 2020 / Revised: 4 November 2020 / Accepted: 10 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Molecular Biology and Chemistry of Mycotoxins and Phytotoxins)
Ochratoxin A (OTA) is one of the worldwide most important mycotoxins in terms of health and agroeconomic consequences. With the aim to promote the use of phytochemicals as alternatives to synthetic fungicides, the effect of hydroxycinnamic acids on the fungal growth and OTA yield by two major OTA-producing species was investigated. After a first step dedicated to the definition of most suitable culture conditions, the impact of 0.5 mM ferulic (FER), p-coumaric (COUM), caffeic and chlorogenic acids was evaluated on Aspergillus westerdijkiae and Penicillium verrucosum. Whereas no fungal growth reduction was observed regardless of the phenolic acid and fungal isolate, our results demonstrated the capacity of FER and COUM to inhibit OTA production. The most efficient compound was FER that led to a 70% reduction of OTA yielded by P. verrucosum and, although not statistically significant, a 35% inhibition of OTA produced by A. westerdijkiae. To further investigate the bioactivity of FER and COUM, their metabolic fate was characterized in fungal broths. The capacity of P. verrucosum to metabolize FER and COUM through a C2-clivage type degradation was demonstrated. Overall, our data support the potential use of FER to prevent OTA contamination and reduce the use of synthetic pesticides. View Full-Text
Keywords: Aspergillus westerdijkiae; Penicillium verrucosum; ochratoxin A; phenolic acids Aspergillus westerdijkiae; Penicillium verrucosum; ochratoxin A; phenolic acids
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MDPI and ACS Style

Boonmee, S.; Atanasova, V.; Chéreau, S.; Marchegay, G.; Hyde, K.D.; Richard-Forget, F. Efficiency of Hydroxycinnamic Phenolic Acids to Inhibit the Production of Ochratoxin A by Aspergillus westerdijkiae and Penicillium verrucosum. Int. J. Mol. Sci. 2020, 21, 8548. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228548

AMA Style

Boonmee S, Atanasova V, Chéreau S, Marchegay G, Hyde KD, Richard-Forget F. Efficiency of Hydroxycinnamic Phenolic Acids to Inhibit the Production of Ochratoxin A by Aspergillus westerdijkiae and Penicillium verrucosum. International Journal of Molecular Sciences. 2020; 21(22):8548. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228548

Chicago/Turabian Style

Boonmee, Saranyaphat, Vessela Atanasova, Sylvain Chéreau, Gisèle Marchegay, Kevin D. Hyde, and Florence Richard-Forget. 2020. "Efficiency of Hydroxycinnamic Phenolic Acids to Inhibit the Production of Ochratoxin A by Aspergillus westerdijkiae and Penicillium verrucosum" International Journal of Molecular Sciences 21, no. 22: 8548. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228548

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