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Review

The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 1XU, UK
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Int. J. Mol. Sci. 2020, 21(22), 8804; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228804
Received: 17 October 2020 / Revised: 11 November 2020 / Accepted: 13 November 2020 / Published: 20 November 2020
During development, the precise control of tissue morphogenesis requires changes in the cell number, size, shape, position, and gene expression, which are driven by both chemical and mechanical cues from the surrounding microenvironment. Such physical and architectural features inform cells about their proliferative and migratory capacity, enabling the formation and maintenance of complex tissue architecture. In polarised epithelia, the apical cell cortex, a thin actomyosin network that lies directly underneath the apical plasma membrane, functions as a platform to facilitate signal transmission between the external environment and downstream signalling pathways. One such signalling pathway culminates in the regulation of YES-associated protein (YAP) and TAZ transcriptional co-activators and their sole Drosophila homolog, Yorkie, to drive proliferation and differentiation. Recent studies have demonstrated that YAP/Yorkie exhibit a distinct function at the apical cell cortex. Here, we review recent efforts to understand the mechanisms that regulate YAP/Yki at the apical cell cortex of epithelial cells and how normal and disturbed YAP–actomyosin networks are involved in eye development and disease. View Full-Text
Keywords: apical cortex; actomyosin; eye development apical cortex; actomyosin; eye development
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MDPI and ACS Style

Skouloudaki, K.; Papadopoulos, D.K.; Hurd, T.W. The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis. Int. J. Mol. Sci. 2020, 21, 8804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228804

AMA Style

Skouloudaki K, Papadopoulos DK, Hurd TW. The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis. International Journal of Molecular Sciences. 2020; 21(22):8804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228804

Chicago/Turabian Style

Skouloudaki, Kassiani, Dimitrios K. Papadopoulos, and Toby W. Hurd 2020. "The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis" International Journal of Molecular Sciences 21, no. 22: 8804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21228804

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