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Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia

Sezione di Istologia ed Embriologia, Dipartimento di Scienze della Vita e Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
DAHFMO-Unità di Istologia ed Embriologia Medica, Sapienza Università di Roma, 00161 Roma, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8865;
Received: 9 October 2020 / Revised: 13 November 2020 / Accepted: 20 November 2020 / Published: 23 November 2020
(This article belongs to the Special Issue Musculoskeletal Aging and Sarcopenia in the Elderly)
Sarcopenia that occurs with advancing age is characterized by a gradual loss of muscle protein component due to the activation of catabolic pathways, increased level of inflammation, and mitochondrial dysfunction. Experimental evidence demonstrates that several physio-pathological processes involved in the onset of sarcopenia may be counteracted by the intake of specific amino acids or antioxidant molecules, suggesting that diet may represent an effective strategy for improving the anabolic response of muscle during aging. The non-essential amino acid taurine is highly expressed in several mammalian tissues, including skeletal muscle where it is involved in the ion channel regulation, in the modulation of intracellular calcium concentration, and where it plays an important role as an antioxidant and anti-inflammatory factor. Here, with the purpose to reproduce the chronic low-grade inflammation characteristics of senescent muscle in an in vitro system, we exploited the role of Tumor Necrosis Factor α (TNF) and we analyzed the effect of taurine in the modulation of different signaling pathways known to be dysregulated in sarcopenia. We demonstrated that the administration of high levels of taurine in myogenic L6 cells stimulates the differentiation process by downregulating the expression of molecules involved in inflammatory pathways and modulating processes such as autophagy and apoptosis. Although further studies are currently ongoing in our laboratory to better elucidate the molecular mechanisms responsible for the positive effect of taurine on myogenic differentiation, this study suggests that taurine supplementation may represent a strategy to delay the loss of mass and functionality characteristic of senescent muscles. View Full-Text
Keywords: skeletal muscle; aging; nutrition; inflammation; antioxidants; autophagy skeletal muscle; aging; nutrition; inflammation; antioxidants; autophagy
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MDPI and ACS Style

Barbiera, A.; Sorrentino, S.; Lepore, E.; Carfì, A.; Sica, G.; Dobrowolny, G.; Scicchitano, B.M. Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia. Int. J. Mol. Sci. 2020, 21, 8865.

AMA Style

Barbiera A, Sorrentino S, Lepore E, Carfì A, Sica G, Dobrowolny G, Scicchitano BM. Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia. International Journal of Molecular Sciences. 2020; 21(22):8865.

Chicago/Turabian Style

Barbiera, Alessandra, Silvia Sorrentino, Elisa Lepore, Andrea Carfì, Gigliola Sica, Gabriella Dobrowolny, and Bianca M. Scicchitano. 2020. "Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia" International Journal of Molecular Sciences 21, no. 22: 8865.

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