Next Article in Journal
The Immune Endocannabinoid System of the Tumor Microenvironment
Next Article in Special Issue
Neurosteroids and Focal Epileptic Disorders
Previous Article in Journal
The Predicted Functional Compartmentation of Rice Terpenoid Metabolism by Trans-Prenyltransferase Structural Analysis, Expression and Localization
Previous Article in Special Issue
Effects of Chronic Intracerebroventricular Infusion of RFamide-Related Peptide-3 on Energy Metabolism in Male Mice
Article

Tumor Necrosis Factor α and Interleukin-1β Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus

1
Departamento de Fisiologia e Biofísica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil
2
Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-900, Brazil
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 8928; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21238928
Received: 9 November 2020 / Revised: 19 November 2020 / Accepted: 20 November 2020 / Published: 25 November 2020
(This article belongs to the Special Issue Effects of Hormones on the Nervous System and Behavior)
Obesity-associated low-grade inflammation favors weight gain, whereas systemic infection frequently leads to anorexia. Thus, inflammatory signals can either induce positive or negative energy balance. In this study, we used whole-cell patch-clamp to investigate the acute effects of three important proinflammatory cytokines, tumor necrosis factor α (TNF-α), interleukin-6, and interleukin-1β (IL-1β) on the membrane excitability of agouti-related peptide (AgRP)- or proopiomelanocortin (POMC)-producing neurons. We found that both TNF-α and IL-1β acutely inhibited the activity of 35–42% of AgRP-producing neurons, whereas very few POMC neurons were depolarized by TNF-α. Interleukin-6 induced no acute changes in the activity of AgRP or POMC neurons. Our findings indicate that the effect of TNF-α and IL-1β, especially on the activity of AgRP-producing neurons, may contribute to inflammation-induced anorexia observed during acute inflammatory conditions. View Full-Text
Keywords: cytokines; inflammation; interleukin-6; obesity; POMC; sepsis cytokines; inflammation; interleukin-6; obesity; POMC; sepsis
Show Figures

Figure 1

MDPI and ACS Style

Chaves, F.M.; Mansano, N.S.; Frazão, R.; Donato, J., Jr. Tumor Necrosis Factor α and Interleukin-1β Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus. Int. J. Mol. Sci. 2020, 21, 8928. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21238928

AMA Style

Chaves FM, Mansano NS, Frazão R, Donato J Jr.. Tumor Necrosis Factor α and Interleukin-1β Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus. International Journal of Molecular Sciences. 2020; 21(23):8928. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21238928

Chicago/Turabian Style

Chaves, Fernanda M.; Mansano, Naira S.; Frazão, Renata; Donato, Jose, Jr. 2020. "Tumor Necrosis Factor α and Interleukin-1β Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus" Int. J. Mol. Sci. 21, no. 23: 8928. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21238928

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop