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A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors
Review

The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells

1
Department of Biological Sciences, Augusta University, Augusta, GA 30912, USA
2
Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA
3
Research Service, Charlie Norwood VA Medical Center, Augusta, GA 30904, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9310; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239310
Received: 5 November 2020 / Revised: 4 December 2020 / Accepted: 4 December 2020 / Published: 7 December 2020
(This article belongs to the Special Issue GRKs and Arrestins in Human Health and Disease)
β-Arrestins (ARRBs) are ubiquitously expressed scaffold proteins that mediate inactivation of G-protein-coupled receptor signaling, and in certain circumstances, G-protein independent pathways. Intriguingly, the two known ARRBs, β-arrestin1 (ARRB1) and β-Arrestin2 (ARRB2), seem to have opposing functions in regulating signaling cascades in several models in health and disease. Recent evidence suggests that ARRBs are implicated in regulating stem cell maintenance; however, their role, although crucial, is complex, and there is no universal model for ARRB-mediated regulation of stem cell characteristics. For the first time, this review compiles information on the function of ARRBs in stem cell biology and will discuss the role of ARRBs in regulating cell signaling pathways implicated in stem cell maintenance in normal and malignant stem cell populations. Although promising targets for cancer therapy, the ubiquitous nature of ARRBs and the plethora of functions in normal cell biology brings challenges for treatment selectivity. However, recent studies show promising evidence for specifically targeting ARRBs in myeloproliferative neoplasms. View Full-Text
Keywords: β-arrestin1 (ARRB1); β-arrestin2 (ARRB2); stem cell phenotype; self-renewal; cancer stem cells β-arrestin1 (ARRB1); β-arrestin2 (ARRB2); stem cell phenotype; self-renewal; cancer stem cells
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MDPI and ACS Style

Kallifatidis, G.; Mamouni, K.; Lokeshwar, B.L. The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells. Int. J. Mol. Sci. 2020, 21, 9310. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239310

AMA Style

Kallifatidis G, Mamouni K, Lokeshwar BL. The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells. International Journal of Molecular Sciences. 2020; 21(23):9310. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239310

Chicago/Turabian Style

Kallifatidis, Georgios, Kenza Mamouni, and Bal L. Lokeshwar 2020. "The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells" International Journal of Molecular Sciences 21, no. 23: 9310. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239310

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