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Review

Autophagy—A Hidden but Important Actor on Oral Cancer Scene

1
Department of Biochemistry, Faculty of Dental Medicine, University of Medicine and Pharmacy Carol Davila, 8 Eroilor Sanitari Blvd, 050474 Bucharest, Romania
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Department of Complete Denture, Faculty of Dental Medicine, University of Medicine and Pharmacy Carol Davila, 17-23 Calea Plevnei, 010221 Bucharest, Romania
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Department of Orthodontics and Dental-Facial Orthopaedics, Faculty of Dental Medicine, University of Medicine and Pharmacy Carol Davila, 17-23 Calea Plevnei, 010221 Bucharest, Romania
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Department of Fixed Prosthodontics and Occlusion, Faculty of Dental Medicine, University of Medicine and Pharmacy Carol Davila, 17-23 Calea Plevnei, 010221 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9325; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239325
Received: 3 November 2020 / Revised: 26 November 2020 / Accepted: 3 December 2020 / Published: 7 December 2020
The duration of denture use, oral hygiene, smoking and male sex were identified as risk factors for oral mucosal lesions. As it is well known, all the oral mucosal lesions associated with risk factors have an important degree of malignity. Chronic mechanical irritation can be another cause of oral cancer and it is produced by the constant action of a deleterious agent from the oral cavity. Autophagy represents a complex evolutionary conserved catabolic process in which cells self-digest intracellular organelles in order to regulate their normal turnover and remove the damaged ones with compromised function to further maintain homeostasis. Autophagy is modulated by mTOR kinase and indirectly by PI3K/AKT survival pathway. Due to its dual capacity to either induce cell death or promote cell survival, important evidence pointed that autophagy has a two-faced role in response to chemotherapy in cancer. In conclusion, understanding how to overcome cytoprotective autophagy and how to take advantage of autophagic cell death is critical in order to enhance the cancer cells sensitivity to particular therapeutic agents. View Full-Text
Keywords: oral cancer; autophagy; PI3K/AKT/mTOR signaling pathway oral cancer; autophagy; PI3K/AKT/mTOR signaling pathway
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MDPI and ACS Style

Alexandra, T.; Marina, I.M.; Daniela, M.; Ioana, S.I.; Maria, B.; Radu, R.; Maria, T.A.; Tudor, S.; Maria, G. Autophagy—A Hidden but Important Actor on Oral Cancer Scene. Int. J. Mol. Sci. 2020, 21, 9325. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239325

AMA Style

Alexandra T, Marina IM, Daniela M, Ioana SI, Maria B, Radu R, Maria TA, Tudor S, Maria G. Autophagy—A Hidden but Important Actor on Oral Cancer Scene. International Journal of Molecular Sciences. 2020; 21(23):9325. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239325

Chicago/Turabian Style

Alexandra, Totan, Imre M. Marina, Miricescu Daniela, Stanescu I. Ioana, BencZe Maria, Radulescu Radu, Tancu A. Maria, Spinu Tudor, and Greabu Maria. 2020. "Autophagy—A Hidden but Important Actor on Oral Cancer Scene" International Journal of Molecular Sciences 21, no. 23: 9325. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239325

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