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Article

Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage

1
Department of Cell Biology and Histology, Experimental Ophthalmo-Biology Group (GOBE), University of the Basque Country UPV/EHU, 48940 Leioa, Vizcaya, Spain
2
Department of Ophthalmology, Araba University Hospital, 01009 Vitoria, Alava, Spain
3
Department of Anatomy and Cell Biology, New York Medical College, Valhalla, NY 10595, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9330; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239330
Received: 27 October 2020 / Revised: 25 November 2020 / Accepted: 3 December 2020 / Published: 7 December 2020
(This article belongs to the Special Issue Molecular Mechanisms of Neural Circuit Development and Regeneration)
RNA binding protein with multiple splicing (RBPMS) is expressed exclusively in retinal ganglion cells (RGCs) in the retina and can label all RGCs in normal retinas of mice, rats, guinea pigs, rabbits, cats, and monkeys, but its function in these cells is not known. As a result of the limited knowledge regarding RBPMS, we analyzed the expression of RBPMS in the retina of different mammalian species (humans, pigs, and rats), in various stages of development (neonatal and adult) and with different levels of injury (control, hypoxia, and organotypic culture or explants). In control conditions, RBPMS was localized in the RGCs somas in the ganglion cell layer, whereas in hypoxic conditions, it was localized in the RGCs dendrites in the inner plexiform layer. Such differential distributions of RBPMS occurred in all analyzed species, and in adult and neonatal retinas. Furthermore, we demonstrate RBPMS localization in the degenerating RGCs axons in the nerve fiber layer of retinal explants. This is the first evidence regarding the possible transport of RBPMS in response to physiological damage in a mammalian retina. Therefore, RBPMS should be further investigated in relation to its role in axonal and dendritic degeneration. View Full-Text
Keywords: RNA binding protein with multiple splicing; retinal ganglion cells; development; inner plexiform layer; ganglion cell layer RNA binding protein with multiple splicing; retinal ganglion cells; development; inner plexiform layer; ganglion cell layer
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MDPI and ACS Style

Pereiro, X.; Ruzafa, N.; Urcola, J.H.; Sharma, S.C.; Vecino, E. Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage. Int. J. Mol. Sci. 2020, 21, 9330. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239330

AMA Style

Pereiro X, Ruzafa N, Urcola JH, Sharma SC, Vecino E. Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage. International Journal of Molecular Sciences. 2020; 21(23):9330. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239330

Chicago/Turabian Style

Pereiro, Xandra, Noelia Ruzafa, J. H. Urcola, Sansar C. Sharma, and Elena Vecino. 2020. "Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage" International Journal of Molecular Sciences 21, no. 23: 9330. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21239330

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