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Article

Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease

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Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA
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Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA
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Insight Research Center, Insight Institute of Neurosurgery & Neuroscience, Flint, MI 48507, USA
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Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USA
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Field Neurosciences Institute, Ascension St. Mary’s, Saginaw, MI 48604, USA
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College of Health and Human Services, Saginaw Valley State University, Saginaw, MI 48710, USA
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College of Medicine, Central Michigan University, Mount Pleasant, MI 48859, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(24), 9542; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249542
Received: 20 November 2020 / Revised: 9 December 2020 / Accepted: 11 December 2020 / Published: 15 December 2020
(This article belongs to the Collection Neuroinflammatory Processes in Neurodegenerative Diseases)
Huntington’s disease (HD) is a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms, accompanied by massive neuronal degeneration in the striatum. In this study, we utilized solid lipid curcumin particles (SLCPs) and solid lipid particles (SLPs) to test their efficacy in reducing deficits in YAC128 HD mice. Eleven-month-old YAC128 male and female mice were treated orally with SLCPs (100 mg/kg) or equivalent volumes of SLPs or vehicle (phosphate-buffered saline) every other day for eight weeks. Learning and memory performance was assessed using an active-avoidance task on week eight. The mice were euthanized, and their brains were processed using Golgi-Cox staining to study the morphology of medium spiny neurons (MSNs) and Western blots to quantify amounts of DARPP-32, brain-derived neurotrophic factor (BDNF), TrkB, synaptophysin, and PSD-95. We found that both SLCPs and SLPs improved learning and memory in HD mice, as measured by the active avoidance task. We also found that SLCP and SLP treatments preserved MSNs arborization and spinal density and modulated synaptic proteins. Our study shows that SLCPs, as well as the lipid particles, can have therapeutic effects in old YAC128 HD mice in terms of recovering from HD brain pathology and cognitive deficits. View Full-Text
Keywords: Huntington’s disease; curcumin; lipids; YAC128; MSNs Huntington’s disease; curcumin; lipids; YAC128; MSNs
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MDPI and ACS Style

Gharaibeh, A.; Maiti, P.; Culver, R.; Heileman, S.; Srinageshwar, B.; Story, D.; Spelde, K.; Paladugu, L.; Munro, N.; Muhn, N.; Kolli, N.; Rossignol, J.; Dunbar, G.L. Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease. Int. J. Mol. Sci. 2020, 21, 9542. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249542

AMA Style

Gharaibeh A, Maiti P, Culver R, Heileman S, Srinageshwar B, Story D, Spelde K, Paladugu L, Munro N, Muhn N, Kolli N, Rossignol J, Dunbar GL. Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease. International Journal of Molecular Sciences. 2020; 21(24):9542. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249542

Chicago/Turabian Style

Gharaibeh, Abeer; Maiti, Panchanan; Culver, Rebecca; Heileman, Shiela; Srinageshwar, Bhairavi; Story, Darren; Spelde, Kristin; Paladugu, Leela; Munro, Nikolas; Muhn, Nathan; Kolli, Nivya; Rossignol, Julien; Dunbar, Gary L. 2020. "Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease" Int. J. Mol. Sci. 21, no. 24: 9542. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249542

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