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Review

Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration

1
Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
2
Department of Ophthalmology, Aarhus University Hospital, 8200 Aarhus N, Denmark
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(24), 9752; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249752
Received: 18 November 2020 / Revised: 14 December 2020 / Accepted: 17 December 2020 / Published: 21 December 2020
Age-related macular degeneration (AMD) is the leading cause of blindness affecting the elderly in the Western world. The most severe form of AMD, wet AMD (wAMD), is characterized by choroidal neovascularization (CNV) and acute vision loss. The current treatment for these patients comprises monthly intravitreal injections of anti-vascular endothelial growth factor (VEGF) antibodies, but this treatment is expensive, uncomfortable for the patient, and only effective in some individuals. AMD is a complex disease that has strong associations with the complement system. All three initiating complement pathways may be relevant in CNV formation, but most evidence indicates a major role for the alternative pathway (AP) and for the terminal complement complex, as well as certain complement peptides generated upon complement activation. Since the complement system is associated with AMD and CNV, a complement inhibitor may be a therapeutic option for patients with wAMD. The aim of this review is to (i) reflect on the possible complement targets in the context of wAMD pathology, (ii) investigate the results of prior clinical trials with complement inhibitors for wAMD patients, and (iii) outline important considerations when developing a future strategy for the treatment of wAMD. View Full-Text
Keywords: age-related macular degeneration; complement system; choroidal neovascularization; anti-complement therapy age-related macular degeneration; complement system; choroidal neovascularization; anti-complement therapy
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MDPI and ACS Style

Jensen, E.G.; Jakobsen, T.S.; Thiel, S.; Askou, A.L.; Corydon, T.J. Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration. Int. J. Mol. Sci. 2020, 21, 9752. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249752

AMA Style

Jensen EG, Jakobsen TS, Thiel S, Askou AL, Corydon TJ. Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration. International Journal of Molecular Sciences. 2020; 21(24):9752. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249752

Chicago/Turabian Style

Jensen, Emilie G., Thomas S. Jakobsen, Steffen Thiel, Anne L. Askou, and Thomas J. Corydon 2020. "Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration" International Journal of Molecular Sciences 21, no. 24: 9752. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21249752

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