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Review

Expanding Role of Ubiquitin in Translational Control

1
Department of Biology, Duke University, Durham, NC 27708-0338, USA
2
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(3), 1151; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031151
Received: 11 January 2020 / Revised: 4 February 2020 / Accepted: 5 February 2020 / Published: 9 February 2020
(This article belongs to the Special Issue Translational Control 2.0)
The eukaryotic proteome has to be precisely regulated at multiple levels of gene expression, from transcription, translation, and degradation of RNA and protein to adjust to several cellular conditions. Particularly at the translational level, regulation is controlled by a variety of RNA binding proteins, translation and associated factors, numerous enzymes, and by post-translational modifications (PTM). Ubiquitination, a prominent PTM discovered as the signal for protein degradation, has newly emerged as a modulator of protein synthesis by controlling several processes in translation. Advances in proteomics and cryo-electron microscopy have identified ubiquitin modifications of several ribosomal proteins and provided numerous insights on how this modification affects ribosome structure and function. The variety of pathways and functions of translation controlled by ubiquitin are determined by the various enzymes involved in ubiquitin conjugation and removal, by the ubiquitin chain type used, by the target sites of ubiquitination, and by the physiologic signals triggering its accumulation. Current research is now elucidating multiple ubiquitin-mediated mechanisms of translational control, including ribosome biogenesis, ribosome degradation, ribosome-associated protein quality control (RQC), and redox control of translation by ubiquitin (RTU). This review discusses the central role of ubiquitin in modulating the dynamism of the cellular proteome and explores the molecular aspects responsible for the expanding puzzle of ubiquitin signals and functions in translation. View Full-Text
Keywords: ubiquitin; ribosome; translation regulation; oxidative stress; quality control; ribosomal protein; degradation ubiquitin; ribosome; translation regulation; oxidative stress; quality control; ribosomal protein; degradation
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MDPI and ACS Style

Dougherty, S.E.; Maduka, A.O.; Inada, T.; Silva, G.M. Expanding Role of Ubiquitin in Translational Control. Int. J. Mol. Sci. 2020, 21, 1151. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031151

AMA Style

Dougherty SE, Maduka AO, Inada T, Silva GM. Expanding Role of Ubiquitin in Translational Control. International Journal of Molecular Sciences. 2020; 21(3):1151. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031151

Chicago/Turabian Style

Dougherty, Shannon E., Austin O. Maduka, Toshifumi Inada, and Gustavo M. Silva 2020. "Expanding Role of Ubiquitin in Translational Control" International Journal of Molecular Sciences 21, no. 3: 1151. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031151

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