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Review

Understanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice

1
Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, India
2
Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, India
3
Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai 600006, India
4
Department of Zoology, School of Life-science, Mizoram University, Aizawl 796004, Mizoram, India
5
R&D Wing, Sree Balaji Medical College and Hospital (SBMCH), BIHER, Chromepet, Chennai 600044, Tamil Nadu, India
6
Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
7
Molecular & Cellular Reprogramming Center, Department of Stem Cell & Regenerative Biotechnology, Konkuk University, Seoul 05029, South Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 1153; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031153
Received: 15 January 2020 / Revised: 1 February 2020 / Accepted: 4 February 2020 / Published: 9 February 2020
(This article belongs to the Special Issue Cancer Cell Reprogramming)
Ovarian cancer (OC) is one of the deadliest cancers among women contributing to high risk of mortality, mainly owing to delayed detection. There is no specific biomarker for its detection in early stages. However, recent findings show that over-expression of specificity protein 1 (Sp1) is involved in many OC cases. The ubiquitous transcription of Sp1 apparently mediates the maintenance of normal and cancerous biological processes such as cell growth, differentiation, angiogenesis, apoptosis, cellular reprogramming and tumorigenesis. Sp1 exerts its effects on cellular genes containing putative GC–rich Sp1–binding site in their promoters. A better understanding of the mechanisms underlying Sp1 transcription factor (TF) regulation and functions in OC tumorigenesis could help identify novel prognostic markers, to target cancer stem cells (CSCs) by following cellular reprogramming and enable the development of novel therapies for future generations. In this review, we address the structure, function, and biology of Sp1 in normal and cancer cells, underpinning the involvement of Sp1 in OC tumorigenesis. In addition, we have highlighted the influence of Sp1 TF in cellular reprogramming of iPSCs and how it plays a role in controlling CSCs. This review highlights the drugs targeting Sp1 and their action on cancer cells. In conclusion, we predict that research in this direction will be highly beneficial for OC treatment, and chemotherapeutic drugs targeting Sp1 will emerge as a promising therapy for OC. View Full-Text
Keywords: ovarian cancer; therapeutics approach; cellular reprogramming; transcription factor; Sp1 ovarian cancer; therapeutics approach; cellular reprogramming; transcription factor; Sp1
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MDPI and ACS Style

Vellingiri, B.; Iyer, M.; Devi Subramaniam, M.; Jayaramayya, K.; Siama, Z.; Giridharan, B.; Narayanasamy, A.; Abdal Dayem, A.; Cho, S.-G. Understanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice. Int. J. Mol. Sci. 2020, 21, 1153. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031153

AMA Style

Vellingiri B, Iyer M, Devi Subramaniam M, Jayaramayya K, Siama Z, Giridharan B, Narayanasamy A, Abdal Dayem A, Cho S-G. Understanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice. International Journal of Molecular Sciences. 2020; 21(3):1153. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031153

Chicago/Turabian Style

Vellingiri, Balachandar, Mahalaxmi Iyer, Mohana Devi Subramaniam, Kaavya Jayaramayya, Zothan Siama, Bupesh Giridharan, Arul Narayanasamy, Ahmed Abdal Dayem, and Ssang-Goo Cho. 2020. "Understanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice" International Journal of Molecular Sciences 21, no. 3: 1153. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031153

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