Next Article in Journal
Identification and Pilot Evaluation of Salivary Peptides from Anopheles albimanus as Biomarkers for Bite Exposure and Malaria Infection in Colombia
Next Article in Special Issue
The Vitamin A and D Exposure of Cells Affects the Intracellular Uptake of Aluminum Nanomaterials and Its Agglomeration Behavior: A Chemo-Analytic Investigation
Previous Article in Journal
Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma
Previous Article in Special Issue
Fate Determination of ZnO in Commercial Foods and Human Intestinal Cells
Article

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

1
The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., 620014 Ekaterinburg, Russia
2
The Institute of Natural Sciences, the Ural Federal University, 620000 Ekaterinburg, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 690; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030690
Received: 6 November 2019 / Revised: 17 January 2020 / Accepted: 19 January 2020 / Published: 21 January 2020
(This article belongs to the Special Issue Nanotoxicology and Nanosafety 2.0)
Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development). View Full-Text
Keywords: nanoparticles; lead oxide; inhalation exposure; toxicity nanoparticles; lead oxide; inhalation exposure; toxicity
Show Figures

Figure 1

MDPI and ACS Style

Sutunkova, M.P.; Solovyeva, S.N.; Chernyshov, I.N.; Klinova, S.V.; Gurvich, V.B.; Shur, V.Y.; Shishkina, E.V.; Zubarev, I.V.; Privalova, L.I.; Katsnelson, B.A. Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles. Int. J. Mol. Sci. 2020, 21, 690. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030690

AMA Style

Sutunkova MP, Solovyeva SN, Chernyshov IN, Klinova SV, Gurvich VB, Shur VY, Shishkina EV, Zubarev IV, Privalova LI, Katsnelson BA. Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles. International Journal of Molecular Sciences. 2020; 21(3):690. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030690

Chicago/Turabian Style

Sutunkova, Marina P., Svetlana N. Solovyeva, Ivan N. Chernyshov, Svetlana V. Klinova, Vladimir B. Gurvich, Vladimir Y. Shur, Ekaterina V. Shishkina, Ilya V. Zubarev, Larisa I. Privalova, and Boris A. Katsnelson 2020. "Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles" International Journal of Molecular Sciences 21, no. 3: 690. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030690

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop