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HMGA Genes and Proteins in Development and Evolution
Review

High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network

1
Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127 Trieste, Italy
2
Istituto per l’Endocrinologia e l’Oncologia Sperimentale (IEOS) “G. Salvatore”, Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli “Federico II”, Via Pansini 5, 80131 Napoli, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 717; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030717
Received: 19 December 2019 / Revised: 16 January 2020 / Accepted: 17 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue HMG Proteins in Development and Disease)
High mobility group A (HMGA) proteins are oncofoetal chromatin architectural factors that are widely involved in regulating gene expression. These proteins are unique, because they are highly expressed in embryonic and cancer cells, where they play a relevant role in cell proliferation, stemness, and the acquisition of aggressive tumour traits, i.e., motility, invasiveness, and metastatic properties. The HMGA protein expression levels and activities are controlled by a connected set of events at the transcriptional, post-transcriptional, and post-translational levels. In fact, microRNA (miRNA)-mediated RNA stability is the most-studied mechanism of HMGA protein expression modulation. In this review, we contribute to a comprehensive overview of HMGA-targeting miRNAs; we provide detailed information regarding HMGA gene structural organization and a comprehensive evaluation and description of HMGA-targeting miRNAs, while focusing on those that are widely involved in HMGA regulation; and, we aim to offer insights into HMGA-miRNA mutual cross-talk from a functional and cancer-related perspective, highlighting possible clinical implications. View Full-Text
Keywords: High mobility group A; miRNA; post-transcriptional regulation; cancer High mobility group A; miRNA; post-transcriptional regulation; cancer
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MDPI and ACS Style

Sgarra, R.; Pegoraro, S.; D’Angelo, D.; Ros, G.; Zanin, R.; Sgubin, M.; Petrosino, S.; Battista, S.; Manfioletti, G. High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network. Int. J. Mol. Sci. 2020, 21, 717. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030717

AMA Style

Sgarra R, Pegoraro S, D’Angelo D, Ros G, Zanin R, Sgubin M, Petrosino S, Battista S, Manfioletti G. High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network. International Journal of Molecular Sciences. 2020; 21(3):717. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030717

Chicago/Turabian Style

Sgarra, Riccardo, Silvia Pegoraro, Daniela D’Angelo, Gloria Ros, Rossella Zanin, Michela Sgubin, Sara Petrosino, Sabrina Battista, and Guidalberto Manfioletti. 2020. "High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network" International Journal of Molecular Sciences 21, no. 3: 717. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21030717

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