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Platelet Concentrates in Musculoskeletal Medicine

Laboratorio di Immunoreumatologia e rigenerazione tissutale, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy
Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1328;
Received: 16 December 2019 / Revised: 29 January 2020 / Accepted: 6 February 2020 / Published: 16 February 2020
(This article belongs to the Special Issue Molecular Research on Platelet Activity in Health and Disease)
Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies. View Full-Text
Keywords: platelet-rich plasma; platelet-rich fibrin; preparation; composition; musculoskeletal diseases platelet-rich plasma; platelet-rich fibrin; preparation; composition; musculoskeletal diseases
MDPI and ACS Style

Mariani, E.; Pulsatelli, L. Platelet Concentrates in Musculoskeletal Medicine. Int. J. Mol. Sci. 2020, 21, 1328.

AMA Style

Mariani E, Pulsatelli L. Platelet Concentrates in Musculoskeletal Medicine. International Journal of Molecular Sciences. 2020; 21(4):1328.

Chicago/Turabian Style

Mariani, Erminia, and Lia Pulsatelli. 2020. "Platelet Concentrates in Musculoskeletal Medicine" International Journal of Molecular Sciences 21, no. 4: 1328.

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