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Article

Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction

1
Université Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium
2
Université Catholique de Louvain, de Duve Institute, Transgenic Core Facility, av. Hippocrate 75/B1.75.09, B-1200 Brussels, Belgium
3
Université Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, av. Mounier 73/B1.73.16, B-1200 Brussels, Belgium
*
Author to whom correspondence should be addressed.
R. Gualdani and P. Gailly co-directed the study and are co-senior authors.
Int. J. Mol. Sci. 2020, 21(5), 1712; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051712
Received: 23 January 2020 / Revised: 21 February 2020 / Accepted: 27 February 2020 / Published: 3 March 2020
Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic plasticity that are believed to underlie declarative memory. We previously showed that mGluR5 specifically activates channels containing TRPC1, an isoform of the canonical family of Transient Receptor Potential channels highly expressed in the CA1-3 regions of the hippocampus. Using a tamoxifen-inducible conditional knockout model, we show here that the acute deletion of the Trpc1 gene alters the extinction of spatial reference memory. mGluR-induced long-term depression, which is partially responsible for memory extinction, was impaired in these mice. Similar results were obtained in vitro and in vivo by inhibiting the channel by its most specific inhibitor, Pico145. Among the numerous known postsynaptic pathways activated by type I mGluR, we observed that the deletion of Trpc1 impaired the activation of ERK1/2 and the subsequent expression of Arc, an immediate early gene that plays a key role in AMPA receptors endocytosis and subsequent long-term depression. View Full-Text
Keywords: memory extinction; TRPC; long-term depression; mGluR memory extinction; TRPC; long-term depression; mGluR
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MDPI and ACS Style

Yerna, X.; Schakman, O.; Ratbi, I.; Kreis, A.; Lepannetier, S.; de Clippele, M.; Achouri, Y.; Tajeddine, N.; Tissir, F.; Gualdani, R.; Gailly, P. Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction. Int. J. Mol. Sci. 2020, 21, 1712. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051712

AMA Style

Yerna X, Schakman O, Ratbi I, Kreis A, Lepannetier S, de Clippele M, Achouri Y, Tajeddine N, Tissir F, Gualdani R, Gailly P. Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction. International Journal of Molecular Sciences. 2020; 21(5):1712. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051712

Chicago/Turabian Style

Yerna, Xavier, Olivier Schakman, Ikram Ratbi, Anna Kreis, Sophie Lepannetier, Marie de Clippele, Younès Achouri, Nicolas Tajeddine, Fadel Tissir, Roberta Gualdani, and Philippe Gailly. 2020. "Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction" International Journal of Molecular Sciences 21, no. 5: 1712. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051712

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