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Article

GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus

Department of Biomolecular Sciences, University of Urbino Carlo Bo, I-61029 Urbino, Italy
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Int. J. Mol. Sci. 2020, 21(5), 1715; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051715
Received: 7 February 2020 / Accepted: 2 March 2020 / Published: 3 March 2020
(This article belongs to the Special Issue Molecular Mechanisms of Neural Circuit Development and Regeneration)
In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural stem cells (NSCs) throughout the life span and are integrated into the hippocampal network. Adult DG neurogenesis is regulated by multiple intrinsic and extrinsic factors that control NSC proliferation, maintenance, and differentiation into mature neurons. γ-Aminobutyric acid (GABA), released by local interneurons, regulates the development of neurons born in adulthood by activating extrasynaptic and synaptic GABAA receptors. In the present work, patch-clamp and calcium imaging techniques were used to record very immature granule cells of adult rat dentate gyrus for investigating the actual role of GABAA receptor activation in intracellular calcium level regulation at an early stage of maturation. Our findings highlight a novel molecular and electrophysiological mechanism, involving calcium-activated potassium channels (BK) and T-type voltage-dependent calcium channels, through which GABA fine-tunes intracellular calcium homeostasis in rat adult-born granule neurons early during their maturation. This mechanism might be instrumental in promoting newborn cell survival. View Full-Text
Keywords: adult rat; GABA input; T-type voltage-dependent calcium channels; calcium-activated potassium channels; hippocampus; immature neurons; membrane potential oscillations adult rat; GABA input; T-type voltage-dependent calcium channels; calcium-activated potassium channels; hippocampus; immature neurons; membrane potential oscillations
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MDPI and ACS Style

Lattanzi, D.; Di Palma, M.; Cuppini, R.; Ambrogini, P. GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus. Int. J. Mol. Sci. 2020, 21, 1715. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051715

AMA Style

Lattanzi D, Di Palma M, Cuppini R, Ambrogini P. GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus. International Journal of Molecular Sciences. 2020; 21(5):1715. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051715

Chicago/Turabian Style

Lattanzi, Davide; Di Palma, Michael; Cuppini, Riccardo; Ambrogini, Patrizia. 2020. "GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus" Int. J. Mol. Sci. 21, no. 5: 1715. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051715

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