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Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species

Division of Pediatric Oncology/Hematology, Meyer University Children’s Hospital, 50139 Florence, Italy
Department of Health Sciences, University of Florence, 50139 Florence, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 1936;
Received: 31 January 2020 / Revised: 5 March 2020 / Accepted: 10 March 2020 / Published: 12 March 2020
(This article belongs to the Special Issue Nutraceuticals in Cancer and Disease Prevention)
In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction could define the balance between health and disease. Nutrients and dietary components influence epigenetic phenomena and modify drugs response; therefore, these food–host interactions can influence the individual predisposition to disease and its potential therapeutic response. Do nutraceuticals have positive or negative effects during chemotherapy? The use of nutraceutical supplements in cancer patients is a controversial debate without a definitive conclusion to date. During cancer treatment, patients take nutraceuticals to alleviate drug toxicity and improve long-term results. Some nutraceuticals may potentiate the effect of cytotoxic chemotherapy by inducing cell growth arrest, cell differentiation, and alteration of the redox state of cells, but in some cases, high levels of them may interfere with the effectiveness of chemotherapy, making cancer cells less reactive to chemotherapy. In this review, we highlighted the emerging opinions and data on the pros and cons on the use of nutraceutical supplements during chemotherapy. View Full-Text
Keywords: nutraceuticals; cancer; phenolic compounds nutraceuticals; cancer; phenolic compounds
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MDPI and ACS Style

Calvani, M.; Pasha, A.; Favre, C. Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species. Int. J. Mol. Sci. 2020, 21, 1936.

AMA Style

Calvani M, Pasha A, Favre C. Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species. International Journal of Molecular Sciences. 2020; 21(6):1936.

Chicago/Turabian Style

Calvani, Maura, Amada Pasha, and Claudio Favre. 2020. "Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species" International Journal of Molecular Sciences 21, no. 6: 1936.

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