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Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
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Int. J. Mol. Sci. 2020, 21(7), 2334; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072334
Received: 1 March 2020 / Revised: 25 March 2020 / Accepted: 26 March 2020 / Published: 27 March 2020
(This article belongs to the Special Issue Nutraceuticals in Cancer and Disease Prevention)
Ovarian cancer is the most deadly gynecologic cancer among women worldwide. Poor response to current treatment makes it necessary to discover new diagnostic biomarkers to detect the cancer early and develop new and effective prevention strategies. Calcitriol, the active metabolite of vitamin D, protects against multiple cancers through unelucidated mechanisms. The oncogenic long non-coding RNA (lncRNA) CCAT2 (colon cancer associated transcript 2) is overexpressed in ovarian cancer. Here, we foundd that calcitriol inhibited CCAT2 expression in ovarian cancer cell lines. Treatment with calcitriol inhibited ovarian cancer cell proliferation, migration, and invasion. As a result of CCAT2 inhibition, calcitriol decreased the binding of transcription factor TCF7L2 (TCF4) to the MYC promoter, resulting in the repression of c-Myc protein expression. Our results suggest a novel anti-cancer mechanism of vitamin D by targeting CCAT2 in ovarian cancer. The findings may help develop vitamin D as a practical and inexpensive nutraceutical for ovarian cancer prevention. View Full-Text
Keywords: long non-coding RNA; CCAT2; vitamin D; cancer prevention; ovarian cancer long non-coding RNA; CCAT2; vitamin D; cancer prevention; ovarian cancer
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MDPI and ACS Style

Wang, L.; Zhou, S.; Guo, B. Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2. Int. J. Mol. Sci. 2020, 21, 2334. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072334

AMA Style

Wang L, Zhou S, Guo B. Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2. International Journal of Molecular Sciences. 2020; 21(7):2334. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072334

Chicago/Turabian Style

Wang, Liye, Shuang Zhou, and Bin Guo. 2020. "Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2" International Journal of Molecular Sciences 21, no. 7: 2334. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072334

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