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Article

Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures

by 1,2,3,†, 1,4,5,†, 3,6, 3, 3, 3,7,8,* and 1,9,*
1
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
2
Department of Medical Research, Tungs’ Taichung Metro Harbor Hospital, Taichung 433, Taiwan
3
Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
4
Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
5
Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan
6
Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
7
Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
9
Department of Pathology, Taipei Medical University Hospital and College of Medicine, Taipei Medical University, Taipei 110, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(8), 2813; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082813
Received: 20 March 2020 / Revised: 14 April 2020 / Accepted: 14 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Pathophysiology in Colonic Diseases)
Monoamine oxidases (MAOs) including MAOA and MAOB are enzymes located on the outer membranes of mitochondria, which are responsible for catalyzing monoamine oxidation. Recently, increased level of MAOs were shown in several cancer types. However, possible roles of MAOs have not yet been elucidated in the progression and prognosis of colorectal carcinoma (CRC). We therefore analyzed the importance of MAOs in CRC by an in silico analysis and tissue microarrays. Several independent cohorts indicated that high expression of MAOB, but not MAOA, was correlated with a worse disease stage and poorer survival. In total, 203 colorectal adenocarcinoma cases underwent immunohistochemical staining of MAOs, and associations with clinicopathological parameters and patient outcomes were evaluated. We found that MAOB is highly expressed in CRC tissues compared to normal colorectal tissues, and its expression was significantly correlated with a higher recurrence rate and a poor prognosis. Moreover, according to the univariate and multivariate analyses, we found that MAOB could be an independent prognostic factor for overall survival and disease-free survival, and its prognostic value was better than T and N stage. Furthermore, significant positive and negative correlations of MAOB with mesenchymal-type and epithelial-type gene expressions were observed in CRC tissues. According to the highlighted characteristics of MAOB in CRC, MAOB can be used as a novel indicator to predict the progression and prognosis of CRC patients. View Full-Text
Keywords: colorectal cancer; MAOB; prognosis; epithelial-to-mesenchymal transition colorectal cancer; MAOB; prognosis; epithelial-to-mesenchymal transition
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MDPI and ACS Style

Yang, Y.-C.; Chien, M.-H.; Lai, T.-C.; Su, C.-Y.; Jan, Y.-H.; Hsiao, M.; Chen, C.-L. Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures. Int. J. Mol. Sci. 2020, 21, 2813. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082813

AMA Style

Yang Y-C, Chien M-H, Lai T-C, Su C-Y, Jan Y-H, Hsiao M, Chen C-L. Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures. International Journal of Molecular Sciences. 2020; 21(8):2813. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082813

Chicago/Turabian Style

Yang, Yi-Chieh, Ming-Hsien Chien, Tsung-Ching Lai, Chia-Yi Su, Yi-Hua Jan, Michael Hsiao, and Chi-Long Chen. 2020. "Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures" International Journal of Molecular Sciences 21, no. 8: 2813. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082813

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