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Review

Endocrine Disrupting Chemicals and Type 1 Diabetes

1
Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults-University of Modena and Reggio Emilia, Largo del Pozzo, 71-41124 Modena, Italy
2
Post Graduate School of Pediatrics, Department of Medical and Surgical Sciences of the Mothers, Children and Adults—University of Modena and Reggio Emilia, Largo del Pozzo, 71-41124 Modena, Italy
3
Pediatric Unit, Department of Pediatrics—AOU Policlinic of Modena, Largo del Pozzo, 71-41124 Modena, Italy
4
Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults-University of Modena and Reggio Emilia, Largo del Pozzo, 71-41124 Modena, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2937; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082937
Received: 12 March 2020 / Revised: 17 April 2020 / Accepted: 20 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
Type 1 diabetes (T1D) is the most common chronic metabolic disease in children and adolescents. The etiology of T1D is not fully understood but it seems multifactorial. The genetic background determines the predisposition to develop T1D, while the autoimmune process against β-cells seems to be also determined by environmental triggers, such as endocrine disrupting chemicals (EDCs). Environmental EDCs may act throughout different temporal windows as single chemical agent or as chemical mixtures. They could affect the development and the function of the immune system or of the β-cells function, promoting autoimmunity and increasing the susceptibility to autoimmune attack. Human studies evaluating the potential role of exposure to EDCs on the pathogenesis of T1D are few and demonstrated contradictory results. The aim of this narrative review is to summarize experimental and epidemiological studies on the potential role of exposure to EDCs in the development of T1D. We highlight what we know by animals about EDCs’ effects on mechanisms leading to T1D development and progression. Studies evaluating the EDC levels in patients with T1D were also reported. Moreover, we discussed why further studies are needed and how they should be designed to better understand the causal mechanisms and the next prevention interventions. View Full-Text
Keywords: type 1 diabetes; non-obese diabetic (NOD) mice; endocrine disruptors; bisphenol A; pesticides; phthalates; polychlorinated biphenyls; polyfluorinated substances type 1 diabetes; non-obese diabetic (NOD) mice; endocrine disruptors; bisphenol A; pesticides; phthalates; polychlorinated biphenyls; polyfluorinated substances
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MDPI and ACS Style

Predieri, B.; Bruzzi, P.; Bigi, E.; Ciancia, S.; Madeo, S.F.; Lucaccioni, L.; Iughetti, L. Endocrine Disrupting Chemicals and Type 1 Diabetes. Int. J. Mol. Sci. 2020, 21, 2937. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082937

AMA Style

Predieri B, Bruzzi P, Bigi E, Ciancia S, Madeo SF, Lucaccioni L, Iughetti L. Endocrine Disrupting Chemicals and Type 1 Diabetes. International Journal of Molecular Sciences. 2020; 21(8):2937. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082937

Chicago/Turabian Style

Predieri, Barbara, Patrizia Bruzzi, Elena Bigi, Silvia Ciancia, Simona F. Madeo, Laura Lucaccioni, and Lorenzo Iughetti. 2020. "Endocrine Disrupting Chemicals and Type 1 Diabetes" International Journal of Molecular Sciences 21, no. 8: 2937. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082937

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