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Review

Nutrition and Genetics in NAFLD: The Perfect Binomium

1
General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Pad. Granelli, via F Sforza 35, 20122 Milan, Italy
2
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy
3
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milano, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to the manuscript.
Int. J. Mol. Sci. 2020, 21(8), 2986; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082986
Received: 26 March 2020 / Revised: 19 April 2020 / Accepted: 21 April 2020 / Published: 23 April 2020
(This article belongs to the Special Issue Nutrigenomics in Liver Diseases: An Uncharted Territory)
Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The susceptibility to develop NAFLD is highly variable and it is influenced by several cues including environmental (i.e., dietary habits and physical activity) and inherited (i.e., genetic/epigenetic) risk factors. Nonetheless, even intestinal microbiota and its by-products play a crucial role in NAFLD pathophysiology. The interaction of dietary exposure with the genome is referred to as ‘nutritional genomics,’ which encompasses both ‘nutrigenetics’ and ‘nutriepigenomics.’ It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management. View Full-Text
Keywords: nonalcoholic fatty liver disease; nutrigenomics; nutrigenetics; nutriepigenomics; gene-diet interaction nonalcoholic fatty liver disease; nutrigenomics; nutrigenetics; nutriepigenomics; gene-diet interaction
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MDPI and ACS Style

Meroni, M.; Longo, M.; Rustichelli, A.; Dongiovanni, P. Nutrition and Genetics in NAFLD: The Perfect Binomium. Int. J. Mol. Sci. 2020, 21, 2986. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082986

AMA Style

Meroni M, Longo M, Rustichelli A, Dongiovanni P. Nutrition and Genetics in NAFLD: The Perfect Binomium. International Journal of Molecular Sciences. 2020; 21(8):2986. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082986

Chicago/Turabian Style

Meroni, Marica, Miriam Longo, Alice Rustichelli, and Paola Dongiovanni. 2020. "Nutrition and Genetics in NAFLD: The Perfect Binomium" International Journal of Molecular Sciences 21, no. 8: 2986. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082986

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