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Review

Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics

1
Department of Anatomy, Chonnam National University Medical School, Gwangju 61469, Korea
2
School of Medicine and Pharmacy, Tra Vinh University, Tra Vinh City 87000, Vietnam
3
Department of Orthodontics, School of Dentistry, Chonnam National University, Gwangju 61186, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2991; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082991
Received: 19 February 2020 / Revised: 16 April 2020 / Accepted: 18 April 2020 / Published: 23 April 2020
(This article belongs to the Special Issue The Effect of Dietary Factors on Cancer 2.0)
Zinc is a group IIB heavy metal. It is an important regulator of major cell signaling pathways in most mammalian cells, functions as an antioxidant and plays a role in maintaining genomic stability. Zinc deficiency leads to severe diseases in the brain, pancreas, liver, kidneys and reproductive organs. Zinc loss occurs during tumor development in a variety of cancers. The prostate normally contains abundant intracellular zinc and zinc loss is a hallmark of the development of prostate cancer development. The underlying mechanism of this loss is not clearly understood. The knowledge that excess zinc prevents the growth of prostate cancers suggests that zinc-mediated therapeutics could be an effective approach for cancer prevention and treatment, although challenges remain. This review summarizes the specific roles of zinc in several cancer types focusing on prostate cancer. The relationship between prostate cancer and the dysregulation of zinc homeostasis is examined in detail in an effort to understand the role of zinc in prostate cancer. View Full-Text
Keywords: zinc; prostate; prostate cancer; tumor growth; homeostasis zinc; prostate; prostate cancer; tumor growth; homeostasis
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MDPI and ACS Style

To, P.K.; Do, M.H.; Cho, J.-H.; Jung, C. Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics. Int. J. Mol. Sci. 2020, 21, 2991. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082991

AMA Style

To PK, Do MH, Cho J-H, Jung C. Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics. International Journal of Molecular Sciences. 2020; 21(8):2991. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082991

Chicago/Turabian Style

To, Phuong K., Manh H. Do, Jin-Hyoung Cho, and Chaeyong Jung. 2020. "Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics" International Journal of Molecular Sciences 21, no. 8: 2991. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082991

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