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Concept Paper

Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics

1
Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
2
Department of Chemistry, University of Florida, Gainesville, FL 32603, USA
3
Department of Medicine, Division of Gastroenterology, University of Florida, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3248; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093248
Received: 13 April 2020 / Revised: 28 April 2020 / Accepted: 2 May 2020 / Published: 4 May 2020
(This article belongs to the Special Issue Emerging Role of Lipids in Metabolism and Disease)
The aim of this work is to analyze relevant endogenous lipid processing pathways, in the context of the impact that lipids have on drug absorption, their therapeutic use, and utilization in drug delivery. Lipids may serve as biomarkers of some diseases, but they can also provide endogenous therapeutic effects for certain pathological conditions. Current uses and possible clinical benefits of various lipids (fatty acids, steroids, triglycerides, and phospholipids) in cancer, infectious, inflammatory, and neurodegenerative diseases are presented. Lipids can also be conjugated to a drug molecule, accomplishing numerous potential benefits, one being the improved treatment effect, due to joined influence of the lipid carrier and the drug moiety. In addition, such conjugates have increased lipophilicity relative to the parent drug. This leads to improved drug pharmacokinetics and bioavailability, the ability to join endogenous lipid pathways and achieve drug targeting to the lymphatics, inflamed tissues in certain autoimmune diseases, or enable overcoming different barriers in the body. Altogether, novel mechanisms of the lipid role in diseases are constantly discovered, and new ways to exploit these mechanisms for the optimal drug design that would advance different drug delivery/therapy aspects are continuously emerging. View Full-Text
Keywords: lipid; fatty acid; glyceride; steroid; phospholipid; oral drug absorption; prodrug; phospholipase A2 (PLA2) lipid; fatty acid; glyceride; steroid; phospholipid; oral drug absorption; prodrug; phospholipase A2 (PLA2)
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MDPI and ACS Style

Markovic, M.; Ben-Shabat, S.; Aponick, A.; Zimmermann, E.M.; Dahan, A. Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics. Int. J. Mol. Sci. 2020, 21, 3248. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093248

AMA Style

Markovic M, Ben-Shabat S, Aponick A, Zimmermann EM, Dahan A. Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics. International Journal of Molecular Sciences. 2020; 21(9):3248. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093248

Chicago/Turabian Style

Markovic, Milica, Shimon Ben-Shabat, Aaron Aponick, Ellen M. Zimmermann, and Arik Dahan. 2020. "Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics" International Journal of Molecular Sciences 21, no. 9: 3248. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093248

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