Next Article in Journal
Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1
Next Article in Special Issue
Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?
Previous Article in Journal
Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer’s Disease
Previous Article in Special Issue
Sensitivity of the Fasciae to the Endocannabinoid System: Production of Hyaluronan-Rich Vesicles and Potential Peripheral Effects of Cannabinoids in Fascial Tissue
Article

Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms

1
Institute of Hematology “L. e A. Seràgnoli”, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy
2
Unit of Endocrinology and Prevention and Care of Diabetes, Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna, University-Hospital S.Orsola, 40138 Bologna, Italy
3
Institute of Hematology “L. e A. Seràgnoli”, Department of Oncology and Hematology, University-Hospital S.Orsola, 40138 Bologna, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(9), 3399; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093399
Received: 10 April 2020 / Revised: 6 May 2020 / Accepted: 9 May 2020 / Published: 11 May 2020
Growing evidence highlights the endocannabinoid (EC) system involvement in cancer progression. Lipid mediators of this system are secreted by hematopoietic cells, including the ECs 2-arachidonoyl-glycerol (2AG) and arachidonoyl-ethanolamide (AEA), the 2AG metabolite 1AG, and members of N-acylethanolamine (NAE) family—palmitoyl-ethanolamide (PEA) and oleoyl-ethanolamide (OEA). However, the relevance of the EC system in myeloproliferative neoplasms (MPN) was never investigated. We explored the EC plasma profile in 55 MPN patients, including myelofibrosis (MF; n = 41), polycythemia vera (PV; n = 9), and essential thrombocythemia (ET; n = 5) subclasses and in 10 healthy controls (HC). AEA, PEA, OEA, 2AG, and 1AG plasma levels were measured by LC–MS/MS. Overall considered, MPN patients displayed similar EC and NAE levels compared to HC. Nonetheless, AEA levels in MPN were directly associated with the platelet count. MF patients showed higher levels of the sum of 2AG and 1AG compared to ET and PV patients, higher OEA/AEA ratios compared to HC and ET patients, and higher OEA/PEA ratios compared to HC. Furthermore, the sum of 2AG and 1AG positively correlated with JAK2V617F variant allele frequency and splenomegaly in MF and was elevated in high-risk PV patients compared to in low-risk PV patients. In conclusion, our work revealed specific alterations of ECs and NAE plasma profile in MPN subclasses and potentially relevant associations with disease severity. View Full-Text
Keywords: endocannabinoids; N-acylethanolamines; myeloproliferative neoplasms; myelofibrosis; polycythemia vera; essential thrombocythemia endocannabinoids; N-acylethanolamines; myeloproliferative neoplasms; myelofibrosis; polycythemia vera; essential thrombocythemia
Show Figures

Figure 1

MDPI and ACS Style

Forte, D.; Fanelli, F.; Mezzullo, M.; Barone, M.; Corradi, G.; Auteri, G.; Bartoletti, D.; Martello, M.; Ottaviani, E.; Terragna, C.; Curti, A.; Pagotto, U.; Palandri, F.; Cavo, M.; Catani, L. Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms. Int. J. Mol. Sci. 2020, 21, 3399. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093399

AMA Style

Forte D, Fanelli F, Mezzullo M, Barone M, Corradi G, Auteri G, Bartoletti D, Martello M, Ottaviani E, Terragna C, Curti A, Pagotto U, Palandri F, Cavo M, Catani L. Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms. International Journal of Molecular Sciences. 2020; 21(9):3399. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093399

Chicago/Turabian Style

Forte, Dorian, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo, and Lucia Catani. 2020. "Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms" International Journal of Molecular Sciences 21, no. 9: 3399. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21093399

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop