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Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)
Review

A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?

1
Division of Infection and Immunity, School of Biomedical Sciences, The University of Western Australia, Nedlands 6009, Australia
2
Marshall Centre for Infectious Diseases Research and Training, Division of Infection and Immunity, School of Biomedical Sciences, The University of Western Australia, Nedlands 6009, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 214; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010214
Received: 8 November 2020 / Revised: 10 December 2020 / Accepted: 17 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Unravelling the Mysteries of Cytomegalovirus)
Since murine cytomegalovirus (MCMV) was first described in 1954, it has been used to model human cytomegalovirus (HCMV) diseases. MCMV is a natural pathogen of mice that is present in wild mice populations and has been associated with diseases such as myocarditis. The species-specific nature of HCMV restricts most research to cell culture-based studies or to the investigation of non-invasive clinical samples, which may not be ideal for the study of disseminated disease. Initial MCMV research used a salivary gland-propagated virus administered via different routes of inoculation into a variety of mouse strains. This revealed that the genetic background of the laboratory mice affected the severity of disease and altered the extent of subsequent pathology. The advent of genetically modified mice and viruses has allowed new aspects of disease to be modeled and the opportunistic nature of HCMV infection to be confirmed. This review describes the different ways that MCMV has been used to model HCMV diseases and explores the continuing difficulty faced by researchers attempting to model HCMV congenital cytomegalovirus disease using the mouse model. View Full-Text
Keywords: congenital disease; placenta; salivary gland congenital disease; placenta; salivary gland
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MDPI and ACS Style

Fisher, M.A.; Lloyd, M.L. A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie? Int. J. Mol. Sci. 2021, 22, 214. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010214

AMA Style

Fisher MA, Lloyd ML. A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie? International Journal of Molecular Sciences. 2021; 22(1):214. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010214

Chicago/Turabian Style

Fisher, Michelle A., and Megan L. Lloyd 2021. "A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?" International Journal of Molecular Sciences 22, no. 1: 214. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010214

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