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Review

Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions

1
Department of Gynaecology and Obstetrics, Campus Großhadern, Ludwig-Maximilians University of Munich, Marchioninistr. 15, 81377 Munich and Campus Innenstadt: Maistr. 11, 80337 Munich, Germany
2
Department of Gynecology and Obstetrics, Zhongshan Hospital, Fu Dan University School of Medicine, Fenglin Rd. 180, Shanghai 200030, China
3
Center of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Marchioninistr. 15, 81377 Munich, Germany
4
Department of Gynecology and Obstetrics, Medical School, University of Crete, Andrea Kalokerinou 13, 715 00 Giofirakia, Greece
5
Department of Gynecology and Obstetrics, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 433; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010433
Received: 15 December 2020 / Revised: 23 December 2020 / Accepted: 29 December 2020 / Published: 4 January 2021
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology 2.0)
Peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) belong to the transcription factor family, and they are highly expressed in all types of trophoblast during pregnancy. The present review discusses currently published papers that are related to the regulation of PPARs via lipid metabolism, glucose metabolism, and amino acid metabolism to affect trophoblast physiological conditions, including differentiation, maturation, secretion, fusion, proliferation, migration, and invasion. Recent pieces of evidence have proven that the dysfunctions of PPARs in trophoblast lead to several related pregnancy diseases such as recurrent miscarriage, preeclampsia, intrauterine growth restriction, and gestational diabetes mellitus. Moreover, the underlying mechanisms of PPARs in the control of these processes have been discussed as well. Finally, this review’s purposes are to provide more knowledge about the role of PPARs in normal and disturbed pregnancy with trophoblast, so as to find PPAR ligands as a potential therapeutic target in the treatment and prevention of adverse pregnancy outcomes. View Full-Text
Keywords: peroxisome proliferator-activated receptors (PPARs); cytotrophoblast; extravillous trophoblast; functions peroxisome proliferator-activated receptors (PPARs); cytotrophoblast; extravillous trophoblast; functions
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MDPI and ACS Style

Peng, L.; Yang, H.; Ye, Y.; Ma, Z.; Kuhn, C.; Rahmeh, M.; Mahner, S.; Makrigiannakis, A.; Jeschke, U.; von Schönfeldt, V. Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions. Int. J. Mol. Sci. 2021, 22, 433. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010433

AMA Style

Peng L, Yang H, Ye Y, Ma Z, Kuhn C, Rahmeh M, Mahner S, Makrigiannakis A, Jeschke U, von Schönfeldt V. Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions. International Journal of Molecular Sciences. 2021; 22(1):433. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010433

Chicago/Turabian Style

Peng, Lin, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, and Viktoria von Schönfeldt. 2021. "Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions" International Journal of Molecular Sciences 22, no. 1: 433. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010433

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