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Article

CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer

1
N.N. Blokhin National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115478 Moscow, Russia
2
Moscow State Academy of Veterinary Medicine and Biotechnology—MVA named after K.I. Scriabin, 23 Academika Scriabina St., 109472 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 450; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010450
Received: 10 December 2020 / Revised: 29 December 2020 / Accepted: 30 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue The New Molecular Strategies under Development in Thoracic Oncology)
There is an urgent need for identification of new prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). In this study, we evaluated immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis revealed no prognostic value for the markers studied, except CD163 and CD206. At the same time, macrophage markers iNOS and CHID1 were found to be expressed in tumor cells and associated with prognosis. We showed that high iNOS expression is a marker of favorable prognosis for squamous cell lung carcinoma (SCC), and NSCLC in general. Similarly, high CHID1 expression is a marker of good prognosis in adenocarcinoma and in NSCLC in general. Analysis of prognostic significance of a high CHID1/iNOS expression combination showed favorable prognosis with 20 months overall survival of patients from the low CHID1/iNOS expression group. For the first time, we demonstrated that CHID1 can be expressed by NSCLC cells and its high expression is a marker of good prognosis for adenocarcinoma and NSCLC in general. At the same time, high expression of iNOS in tumor cells is a marker of good prognosis in SCC. When used in combination, CHID1 and iNOS show a very good prognostic capacity for NSCLC. We suggest that in the case of lung cancer, tumor-associated macrophages are likely ineffective as a therapeutic target. At the same time, macrophage markers expressed by tumor cells may be considered as targets for anti-tumor therapy or, as in the case of CHID1, as potential anti-tumor agents. View Full-Text
Keywords: lung cancer; stroma; macrophage; chitinase-like protein; prognosis lung cancer; stroma; macrophage; chitinase-like protein; prognosis
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MDPI and ACS Style

Kovaleva, O.V.; Rashidova, M.A.; Samoilova, D.V.; Podlesnaya, P.A.; Tabiev, R.M.; Mochalnikova, V.V.; Gratchev, A. CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer. Int. J. Mol. Sci. 2021, 22, 450. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010450

AMA Style

Kovaleva OV, Rashidova MA, Samoilova DV, Podlesnaya PA, Tabiev RM, Mochalnikova VV, Gratchev A. CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer. International Journal of Molecular Sciences. 2021; 22(1):450. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010450

Chicago/Turabian Style

Kovaleva, Olga V., Madina A. Rashidova, Daria V. Samoilova, Polina A. Podlesnaya, Rasul M. Tabiev, Valeria V. Mochalnikova, and Alexei Gratchev. 2021. "CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer" International Journal of Molecular Sciences 22, no. 1: 450. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010450

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