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FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer

Institute of Biosciences, Newcastle University, Newcastle Upon Tyne NE1 3BZ, UK
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 455;
Received: 27 November 2020 / Revised: 21 December 2020 / Accepted: 24 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Glycobiology of Cancer)
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the innermost GlcNAc residue of N-glycans. FUT8 is frequently upregulated in cancer, and plays a critical role in immune evasion, antibody-dependent cellular cytotoxicity (ADCC), and the regulation of TGF-β, EGF, α3β1 integrin and E-Cadherin. Here, we summarise the role of FUT8 in various cancers (including lung, liver, colorectal, ovarian, prostate, breast, melanoma, thyroid, and pancreatic), discuss the potential mechanisms involved, and outline opportunities to exploit FUT8 as a critical factor in cancer therapeutics in the future. View Full-Text
Keywords: fut8; cancer; glycosylation; fucosylation fut8; cancer; glycosylation; fucosylation
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MDPI and ACS Style

Bastian, K.; Scott, E.; Elliott, D.J.; Munkley, J. FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer. Int. J. Mol. Sci. 2021, 22, 455.

AMA Style

Bastian K, Scott E, Elliott DJ, Munkley J. FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer. International Journal of Molecular Sciences. 2021; 22(1):455.

Chicago/Turabian Style

Bastian, Kayla, Emma Scott, David J. Elliott, and Jennifer Munkley. 2021. "FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer" International Journal of Molecular Sciences 22, no. 1: 455.

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