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Article

Delivery of the Radionuclide 131I Using Cationic Fusogenic Liposomes as Nanocarriers

1
Institute of Biological Information Processing: Mechanobiology (IBI-2) Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
2
Institute of Neurosciences and Medicine: Nuclear Chemistry (INM-5) Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
3
Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 457; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010457
Received: 23 November 2020 / Revised: 30 December 2020 / Accepted: 31 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Functionalized Liposomes)
Liposomes are highly biocompatible and versatile drug carriers with an increasing number of applications in the field of nuclear medicine and diagnostics. So far, only negatively charged liposomes with intercalated radiometals, e.g., 64Cu, 99mTc, have been reported. However, the process of cellular uptake of liposomes by endocytosis is rather slow. Cellular uptake can be accelerated by recently developed cationic liposomes, which exhibit extraordinarily high membrane fusion ability. The aim of the present study was the development of the formulation and the characterization of such cationic fusogenic liposomes with intercalated radioactive [131I]I for potential use in therapeutic applications. The epithelial human breast cancer cell line MDA-MB-231 was used as a model for invasive cancer cells and cellular uptake of [131I]I was monitored in vitro. Delivery efficiencies of cationic and neutral liposomes were compared with uptake of free iodide. The best cargo delivery efficiency (~10%) was achieved using cationic fusogenic liposomes due to their special delivery pathway of membrane fusion. Additionally, human blood cells were also incubated with cationic control liposomes and free [131I]I. In these cases, iodide delivery efficiencies remained below 3%. View Full-Text
Keywords: cationic liposomes; fusogenic liposomes; radioisotope delivery; 131I; cancer cationic liposomes; fusogenic liposomes; radioisotope delivery; 131I; cancer
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MDPI and ACS Style

Kolašinac, R.; Bier, D.; Schmitt, L.; Yabluchanskiy, A.; Neumaier, B.; Merkel, R.; Csiszár, A. Delivery of the Radionuclide 131I Using Cationic Fusogenic Liposomes as Nanocarriers. Int. J. Mol. Sci. 2021, 22, 457. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010457

AMA Style

Kolašinac R, Bier D, Schmitt L, Yabluchanskiy A, Neumaier B, Merkel R, Csiszár A. Delivery of the Radionuclide 131I Using Cationic Fusogenic Liposomes as Nanocarriers. International Journal of Molecular Sciences. 2021; 22(1):457. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010457

Chicago/Turabian Style

Kolašinac, Rejhana, Dirk Bier, Laura Schmitt, Andriy Yabluchanskiy, Bernd Neumaier, Rudolf Merkel, and Agnes Csiszár. 2021. "Delivery of the Radionuclide 131I Using Cationic Fusogenic Liposomes as Nanocarriers" International Journal of Molecular Sciences 22, no. 1: 457. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010457

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