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MicroRNAs as Biomarkers for Nephrotic Syndrome

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
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Int. J. Mol. Sci. 2021, 22(1), 88; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010088
Received: 14 November 2020 / Revised: 19 December 2020 / Accepted: 22 December 2020 / Published: 23 December 2020
(This article belongs to the Special Issue Extracellular Vesicles as a New Source of Liquid Biopsy 2.0)
Nephrotic syndrome represents the clinical situation characterized by presence of massive proteinuria and low serum protein caused by a variety of diseases, including minimal change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS) and membranous glomerulonephropathy. Differentiating between diagnoses requires invasive renal biopsies in general. Even with the biopsy, we encounter difficulties to differentiate MCNS and FSGS in some cases. There is no other better option currently available for the diagnosis other than renal biopsy. MicroRNAs (miRNAs) are no-coding RNAs of approximately 20 nucleotides in length, which regulate target genes in the post-transcriptional processes and have essential roles in many diseases. MiRNAs in serum and urine have been shown as non-invasive biomarkers in multiple diseases, including renal diseases. In this article, we summarize the current knowledge of miRNAs as the promising biomarkers for nephrotic syndrome. View Full-Text
Keywords: microRNA; nephrotic syndrome; biomarker; minimal change nephrotic syndrome; focal segmental glomerulosclerosis; membranous glomerulonephropathy microRNA; nephrotic syndrome; biomarker; minimal change nephrotic syndrome; focal segmental glomerulosclerosis; membranous glomerulonephropathy
MDPI and ACS Style

Tsuji, K.; Kitamura, S.; Wada, J. MicroRNAs as Biomarkers for Nephrotic Syndrome. Int. J. Mol. Sci. 2021, 22, 88. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010088

AMA Style

Tsuji K, Kitamura S, Wada J. MicroRNAs as Biomarkers for Nephrotic Syndrome. International Journal of Molecular Sciences. 2021; 22(1):88. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010088

Chicago/Turabian Style

Tsuji, Kenji, Shinji Kitamura, and Jun Wada. 2021. "MicroRNAs as Biomarkers for Nephrotic Syndrome" International Journal of Molecular Sciences 22, no. 1: 88. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010088

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